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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2017

01-09-2017 | Case Report

Oropharyngeal Syphilis: Imaging and Pathologic Findings in Two Patients

Authors: Enric Ripoll, Carla Montironi, Llucia Alós, Teresa Pujol, Joan Berenguer, Laura Oleaga

Published in: Head and Neck Pathology | Issue 3/2017

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Abstract

Syphilis is a widespread infection with increasing frequency in developed countries, especially among men who have sex with men. We present two cases of oropharyngeal syphilis in two middle-aged men who presented with a painless tonsillar ulcer and progressive enlargement of cervical lymph nodes suspected of being a tonsillar tumour. A pathologic analysis of the ulcer led to an accurate diagnosis. We review the imaging and pathologic findings to emphasize the importance of taking syphilis into account in the differential diagnosis.
Literature
1.
Cohen SE, Klausner JD, Engelman J, et al. Syphilis in the modern era: an update for physicians. Infect Dis Clin N Am. 2013;27(4):705–22.CrossRef
2.
Shockman S, Buescher LS, Stone SP. Syphilis in the United States. Clin Dermatol. 2014;32(2):213–8.CrossRefPubMed
3.
4.
Jang DW, Khan A, Genden EM, et al. Syphilitic lymphadenitis diagnosed via fine needle aspiration biopsy. Diagn Cytopathol. 2011;39(8):603–5.CrossRefPubMed
5.
Morshed MG. Current trend on syphilis diagnosis: issues and challenges. Adv Exp Med Biol. 2014;808:51–64.CrossRefPubMed
6.
Patton ME, Su JR, Nelson R, et al. Primary and secondary syphilis: United States, 2005–2013. MMWR Morb Mortal Wkly Rep. 2014;63(18):402–6.PubMed
7.
Bruce IA, Roper AJ, Gayed SL, et al. Syphilitic cervical lymphadenopathy: return of an old foe. Am J Otolaryngol. 2009;30(5):347–9.CrossRefPubMed
8.
Ikenberg K, Springer E, Bräuninger W, et al. Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant. J Clin Pathol. 2010;63(8):731–6.CrossRefPubMed
9.
Yuan Y, Zhang X, Xu N, et al. Clinical and pathologic diagnosis and different diagnosis of syphilis cervical lymphadenitis. Int J Clin Exp Pathol. 2015;8(10):13635–8.PubMedPubMedCentral
10.
Hamlyn E, Marriott D, Gallagher RM. Secondary syphilis presenting as tonsillitis in three patients. J Laryngol Otol. 2006;120(7):602–4.CrossRefPubMed
11.
Oddó D, Carrasco G, Capdeville F, et al. Syphilitic tonsillitis presenting as an ulcerated tonsillar tumor with ipsilateral lymphadenopathy. Ann Diagn Pathol. 2007;11(5):353–7.CrossRefPubMed
12.
Fu Z, Zhang J, Li Q, Liu M, et al. A case of secondary syphilis involving tonsil, pulmonary, and multiple lymph nodes: 18F-FDG PET/CT findings. Clin Nucl Med. 2015;40(4):335–7.CrossRefPubMed
13.
Pan X, Zhu X, Li QQ. Syphilis manifesting as a nasopharyngeal carcinoma with cervical lymphadenopathy: a case report. Exp Ther Med. 2012;3(6):1023–5.PubMedPubMedCentral
14.
Sato J, Tsubota H, Himi T. Syphilitic cervical lymphadenopathy. Eur Arch Otorhinolaryngol. 2003;260(5):283–5.PubMed
15.
Wang X, Li WQ, Liu HM, et al. Isolated syphilitic cervical lymphadenopathy: report of two cases and review of the literature. J Int Med Res. 2012;40(5):1988–2000.CrossRefPubMed
16.
Kim JM, Lee SM, Bae SB, et al. The role of PET/CT in diagnosing generalized lymphadenopathy in asymptomatic secondary syphilis. Hell J Nucl Med. 2016;19(1):60–2.PubMed
17.
Shimizu T, Shinogi J, Majima Y, et al. Secondary syphilis of the tonsil. Arch Otorhinolaryngol. 1989;246:117.CrossRefPubMed
18.
Barbee LA, Centor RM, Goldberger ZD, et al. Clinical problem-solving. A history lesson. N Engl J Med. 2015;372(14):1360–4.CrossRefPubMed
19.
Yarington CT Jr, Jensen OC. Syphilis as a differential diagnosis of neck masses. Arch Otolaryngol. 1967;86(2):219–21.CrossRefPubMed
Metadata
Title
Oropharyngeal Syphilis: Imaging and Pathologic Findings in Two Patients
Authors
Enric Ripoll
Carla Montironi
Llucia Alós
Teresa Pujol
Joan Berenguer
Laura Oleaga
Publication date
01-09-2017
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2017
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-016-0758-x

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