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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2014

01-09-2014 | Case Report

Extensively Ossifying Oral Leiomyoma: A Rare Histologic Finding

Authors: Lindsay J. Montague, Sarah G. Fitzpatrick, Nadim M. Islam, Donald M. Cohen, Indraneel Bhattacharyya

Published in: Head and Neck Pathology | Issue 3/2014

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Abstract

Oral leiomyoma are rare neoplasms of the oral cavity. Ossification within leiomyoma is not unusual but is mostly reported in leiomyoma of the deep soft tissue. Ossifying leiomyoma is extremely rare in the head and neck. We identified a total of three cases of extensively ossified leiomyoma in the head and neck in the literature including lesions in the lateral pterygoid muscle and orbit. To the best of our knowledge, only one case of extensively calcified leiomyoma has been reported in the oral cavity. We present two such rare cases of oral leiomyoma with extensive intratumoral calcifications and ossification. Ossified leiomyoma should be considered in the differential diagnosis of calcified or hard/firm soft tissue masses in the oral cavity.
Literature
1.
Farman AG. Benign smooth muscle tumours. S Afr Med J. 1975;49(33):1333–40.PubMed
2.
Weiss SW, Goldblum JR. Benign tumors of smooth muscle. In: Weiss SW, Goldblum JR, editors. Engineer and weiss’s soft tissue tumors. 5th ed. Philadelphia: Mosby; 2008.
3.
Baden E, Doyle JL, Lederman DA. Leiomyoma of the oral cavity: a light microscopic and immunohistochemical study with review of the literature from 1884 to 1992. Eur J Cancer B Oral Oncol. 1994;30B(1):1–7.PubMed
4.
Billings SD, Folpe AL, Weiss SW. Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes. Am J Surg Pathol. 2001;25(9):1134–42.PubMedCrossRef
5.
Liu JY, Liao SL, Zheng J. Cutaneous epithelioid angioleiomyoma with clear-cell change. Am J Dermatopathol. 2007;29(2):190–3.PubMedCrossRef
6.
Persaud V, Arjoon PD. Uterine leiomyoma: incidence of degenerative change and a correlation of associated symptoms. Obstet Gynecol. 1970;35(3):432–6.PubMed
7.
Ueda H, Togashi K, Konishi I, Kataoka ML, Koyama T, Fujiwara T, et al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics: a review publication of the Radiological Society of North America, Inc 1999;19 Spec No:S131–45.
8.
Kacerovska D, Michal M, Kreuzberg B, Mukensnabl P, Kazakov DV. Acral calcified vascular leiomyoma of the skin: a rare clinicopathological variant of cutaneous vascular leiomyomas: report of 3 cases. J Am Acad Dermatol. 2008;59(6):1000–4.PubMedCrossRef
9.
Lopez-Barea F, Rodriguez-Peralto JL, Burgos E, Gonzalez-Lopez J. Calcified leiomyoma of deep soft tissue: report of a case in childhood. Virchows Arch. 1994;425(2):217–20.PubMedCrossRef
10.
Miki Y, Abe S, Tokizaki T, Harasawa A, Imamura T, Matsushita T. Imaging characteristics of calcified leiomyoma of deep soft tissue. J Orthop Sci. 2007;12(6):601–5.PubMedCrossRef
11.
Mutrie CJ, Donahue DM, Wain JC, Wright CD, Gaissert HA, Grillo HC, et al. Esophageal leiomyoma: a 40-year experience. Ann Thorac Surg. 2005;79(4):1122–5.PubMedCrossRef
12.
Yamato M, Nishimura G, Koguchi Y, Saotome K. Calcified leiomyoma of deep soft tissue in a child. Pediatr Radiol. 1999;29(2):135–7.PubMedCrossRef
13.
Nonaka CF, Pereira KM, Miguel MC. Oral vascular leiomyoma with extensive calcification areas. Braz J Otorhinolaryngol. 2010;76(4):539.PubMedCrossRef
14.
Cherrick HM, Dunlap CL, King OH Jr. Leiomyomas of the oral cavity: review of the literature and clinicopathologic study of seven new cases. Oral Surg Oral Med Oral Pathol. 1973;35(1):54–66.PubMedCrossRef
15.
Bhattacharyya I, Summerlin DJ, Cohen DM, Ellis GL, Bavitz JB, Gillham LL. Granular cell leiomyoma of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(3):353–9.PubMedCrossRef
16.
Dobashi Y, Iwabuchi K, Nakahata J, Yanagimoto K, Kameya T. Combined clear and granular cell leiomyoma of soft tissue: evidence of transformation to a histiocytic phenotype. Histopathology. 1999;34(6):526–31.PubMedCrossRef
17.
Koutlas IG, Manivel JC. Epithelioid leiomyoma of the oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(6):670–3.PubMedCrossRef
18.
Mentzel T, Wadden C, Fletcher CD. Granular cell change in smooth muscle tumours of skin and soft tissue. Histopathology. 1994;24(3):223–31.PubMedCrossRef
19.
Vincenzi A, Rossi G, Monzani D, Longo L, Rivasi F. Atypical (bizarre) leiomyoma of the nasal cavity with prominent myxoid change. J Clin Pathol. 2002;55(11):872–5.PubMedCentralPubMedCrossRef
20.
Casillas J, Joseph RC, Guerra JJ Jr. CT appearance of uterine leiomyomas. Radiographics. 1990;10(6):999–1007.PubMedCrossRef
21.
Weiss SW. Smooth muscle tumors of soft tissue. Adv Anatomic Pathol. 2002;9(6):351–9.CrossRef
22.
Brooks JK, Nikitakis NG, Goodman NJ, Levy BA. Clinicopathologic characterization of oral angioleiomyomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(2):221–7.PubMedCrossRef
23.
Lloria-Benet M, Bagan JV, Lloria de Miguel E, Borja-Morant A, Alonso S. Oral leiomyoma: a case report. Medicina oral: organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal 2003;8(3):215–9.
24.
Manojlovic S, Aljinovic-Ratkovic N, Kruslin B. Calcified leiomyoma of the lateral pterygoid muscle in an 8-year-old boy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(2):199–203.PubMedCrossRef
25.
Ghahremani GG, Meyers MA, Port RB. Calcified primary tumors of the gastrointestinal tract. Gastrointest Radiol. 1978;2(4):331–9.PubMed
26.
Xu Y, Lacouture M, Petronic-Rosic V, Soltani K, Shea CR. Ossified soft tissue leiomyoma in a patient with sickle cell anemia. J Cutan Pathol. 2005;32(10):696–9.PubMedCrossRef
27.
Gupta AK, Berry M, Mitra DK. Ossified gastric leiomyoma in a child: a case report. Pediatr Radiol. 1995;25(1):48–9.PubMedCrossRef
28.
Kilpatrick SE, Mentzel T, Fletcher CD. Leiomyoma of deep soft tissue. Clinicopathologic analysis of a series. Am J Surg Pathol. 1994;18(6):576–82.PubMedCrossRef
29.
Lubbers PR, Chandra R, Markle BM, Downey EF Jr, Malawer M. Case report 421: calcified leiomyoma of the soft tissues of the right buttock. Skeletal Radiol. 1987;16(3):252–6.PubMedCrossRef
30.
Fanburg-Smith JC, Lasota J, Auerbach A, Foss RD, Laskin WB, Murphey MD. Tumors and tumor-like lesions of the soft tissues. In: Barnes L, editor. Surgical pathology of the head and neck. 3rd ed. New York: Informal Healthcare; 2009.
31.
Nonaka CF, Pacheco DF, Nunes RP, Freitas Rde A, Miguel MC. Ossifying fibromyxoid tumor in the mandibular gingiva: case report and review of the literature. J Periodontol. 2009;80(4):687–92.PubMedCrossRef
32.
Williams SB, Ellis GL, Meis JM, Heffner DK. Ossifying fibromyxoid tumour (of soft parts) of the head and neck: a clinicopathological and immunohistochemical study of nine cases. J Laryngol Otol. 1993;107(1):75–80.PubMedCrossRef
33.
Perez-Montiel MD, Plaza JA, Dominguez-Malagon H, Suster S. Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue. Am J Dermatopathol. 2006;28(2):105–11.PubMedCrossRef
34.
Wiechens B, Werner JA, Luttges J, Rudert H, Rochels R. Primary orbital leiomyoma and leiomyosarcoma. Ophthalmologica. Journal international d’ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 1999;213(3):159–64.
Metadata
Title
Extensively Ossifying Oral Leiomyoma: A Rare Histologic Finding
Authors
Lindsay J. Montague
Sarah G. Fitzpatrick
Nadim M. Islam
Donald M. Cohen
Indraneel Bhattacharyya
Publication date
01-09-2014
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2014
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-013-0497-1

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