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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2012

01-09-2012 | Original Paper

Correlation Between Dysplasia and Ploidy Status in Oral Leukoplakia

Authors: Andre W. van Zyl, Marlene B. van Heerden, Emil Langenegger, Willie F. P. van Heerden

Published in: Head and Neck Pathology | Issue 3/2012

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Abstract

Oral leukoplakia and other potentially malignant disorders (PMD) may progress to oral squamous cell carcinoma (OSCC). The gold standard for assessing the potential for malignant transformation remains histologic examination with the aim of grading the dysplastic changes. However, not all lesions with dysplasia will progress to OSCC. DNA ploidy has been suggested as a method to predict the clinical behaviour of PMD. This study reports on the use of high-resolution flow cytometry to determine the ploidy status of formalin-fixed, paraffin-embedded material from PMD compared to their dysplasia grade on histology. Aneuploidy was found in 13 % of mild, 31 % of moderate, and 54 % of severe dysplasia cases. This difference was statistically significant (p = 0.011). The differences in ploidy status were more significant when grouping the dysplasia into low-risk and high-risk categories (p = 0.008). These findings indicate that the ploidy status of PMD as determined by high-resolution flow cytometry may be of value in predicting biological behaviour in PMD such as leukoplakia.
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Metadata
Title
Correlation Between Dysplasia and Ploidy Status in Oral Leukoplakia
Authors
Andre W. van Zyl
Marlene B. van Heerden
Emil Langenegger
Willie F. P. van Heerden
Publication date
01-09-2012
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2012
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-012-0352-9

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