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01-03-2012 | Case Report

Ganglioneuroblastic Transformation in Olfactory Neuroblastoma

Authors: Timothy Bates, Daniel Du Plessis, Tuomo Polvikoski, Philip Sloan, Andrew McQueen, David Meikle, Charles Kelly, Max Robinson

Published in: Head and Neck Pathology | Issue 1/2012

Abstract

Ganglioneuroblastic transformation in olfactory neuroblastoma (ONB) is an exceptionally rare phenomenon. We document the case of a patient with a poorly differentiated sinonasal malignancy that recurred following treatment with chemoradiotherapy and showed ganglioneuroblastic transformation. Although the index tumour showed neuroendocrine differentiation, it did not have the typical clinico-pathological features associated with ONB. We highlight the diagnostic difficulties in establishing an accurate diagnosis for undifferentiated sinonasal tumours and present evidence that the index tumour was an ONB. The current report is only the third case of ONB showing complete ganglioneuroblastic transformation.

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Title: Ganglioneuroblastic Transformation in Olfactory Neuroblastoma
Authors: Timothy Bates
Daniel Du Plessis
Tuomo Polvikoski
Philip Sloan
Andrew McQueen
David Meikle
Charles Kelly
Max Robinson
Publication date: 01-03-2012
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 1/2012
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-011-0293-8

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Ganglioneuroblastic Transformation in Olfactory Neuroblastoma

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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