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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2009

01-09-2009 | Original Paper

Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 Cases

Authors: Hope H. Wu, Samiah Zafar, Youming Huan, Herman Yee, Luis Chiriboga, Beverly Y. Wang

Published in: Head and Neck Pathology | Issue 3/2009

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Abstract

Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.
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Metadata
Title
Fascin Over Expression is Associated with Dysplastic Changes in Sinonasal Inverted Papillomas: A Study of 47 Cases
Authors
Hope H. Wu
Samiah Zafar
Youming Huan
Herman Yee
Luis Chiriboga
Beverly Y. Wang
Publication date
01-09-2009
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 3/2009
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-009-0133-2

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