Skip to main content
Top
Published in: Head and Neck Pathology 4/2008

01-12-2008 | Meeting Report

Hereditary Paraganglioma of the Nasopharynx

Authors: Nasser Said-Al-Naief, Junu Ojha

Published in: Head and Neck Pathology | Issue 4/2008

Login to get access

Abstract

Head and neck paragangliomas are rare neuroendocrine tumors derived from neural crest cells of parasympathetic ganglia or the widely dispersed neuroendocrine cells of the head and neck region. Paragangliomas of the sinonasal tract and nasopharynx are rare. The clinicopathologic features of this unique example of a hereditary, nasopharyngeal paraganglioma, and selective entities that are included in its differential diagnosis are presented.
Literature
1.
go back to reference Astuti F, Latif A, Dallol PL, et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial phaeochromocytoma and to familial paraganglioma. Am J Hum Genet. 2001;69:49–54.PubMedCrossRef Astuti F, Latif A, Dallol PL, et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial phaeochromocytoma and to familial paraganglioma. Am J Hum Genet. 2001;69:49–54.PubMedCrossRef
2.
go back to reference Barnes L, Eveson JW, Reichart P, Sidransky D. Head and neck tumors. In: Gnepp DRE, editor. World health organization classification of tumors pathology & genetics. Lyon, France: IARC Press; 2005. p. 361–70. Barnes L, Eveson JW, Reichart P, Sidransky D. Head and neck tumors. In: Gnepp DRE, editor. World health organization classification of tumors pathology & genetics. Lyon, France: IARC Press; 2005. p. 361–70.
3.
go back to reference Suarez C, Rodrigo JP, Ferlito A, et al. Tumours of familial origin in the head and neck. Oral Oncol. 2006;42(10):965–78.PubMedCrossRef Suarez C, Rodrigo JP, Ferlito A, et al. Tumours of familial origin in the head and neck. Oral Oncol. 2006;42(10):965–78.PubMedCrossRef
4.
go back to reference Lack EE, Cubilla AL, Woodruff JM. Paragangliomas of the head and neck region: a pathologic study of tumors from 71 patients. Hum Pathol. 1979;10:191–218.PubMedCrossRef Lack EE, Cubilla AL, Woodruff JM. Paragangliomas of the head and neck region: a pathologic study of tumors from 71 patients. Hum Pathol. 1979;10:191–218.PubMedCrossRef
5.
go back to reference Pellitteri PK, Ferlito A, Bradley PJ, et al. Management of sarcomas of the head and neck in adults. Oral Oncol. 2003;39(1):2–12.PubMedCrossRef Pellitteri PK, Ferlito A, Bradley PJ, et al. Management of sarcomas of the head and neck in adults. Oral Oncol. 2003;39(1):2–12.PubMedCrossRef
6.
go back to reference Bikhazi PH, Roeder E, Attaie A, Lalwani AK. Familial paragangliomas: the emerging impact of molecular genetics on evaluation and management. Am J Otol. 1999;20(5):639–43.PubMed Bikhazi PH, Roeder E, Attaie A, Lalwani AK. Familial paragangliomas: the emerging impact of molecular genetics on evaluation and management. Am J Otol. 1999;20(5):639–43.PubMed
7.
go back to reference Grufferman S, Gillman MW, Pasternak LR, et al. Familial carotid body tumors: case report and epidemiologic review. Cancer. 1980;46(9):2116–22.PubMedCrossRef Grufferman S, Gillman MW, Pasternak LR, et al. Familial carotid body tumors: case report and epidemiologic review. Cancer. 1980;46(9):2116–22.PubMedCrossRef
8.
go back to reference Amar L, et al. Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol. 2005;34:8812–8.CrossRef Amar L, et al. Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol. 2005;34:8812–8.CrossRef
9.
go back to reference Drucker A, Houlden R. A case of familial paraganglioma syndrome type 4 caused by a mutation in the SDHB gene. Nat Clin Pract Endocrinol Metab. 2006;2:702–6.PubMedCrossRef Drucker A, Houlden R. A case of familial paraganglioma syndrome type 4 caused by a mutation in the SDHB gene. Nat Clin Pract Endocrinol Metab. 2006;2:702–6.PubMedCrossRef
10.
go back to reference Benn DE, Gimenez-Roqueplo AP, Reilly JR, et al. Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes. J Clin Endocrinol Metab. 2006;91(3):827–36.PubMedCrossRef Benn DE, Gimenez-Roqueplo AP, Reilly JR, et al. Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes. J Clin Endocrinol Metab. 2006;91(3):827–36.PubMedCrossRef
11.
go back to reference Welkoborsky HJ, Gosepath J, Jacob R, et al. Biologic characteristics of paragangliomas of the nasal cavity and paranasal sinuses. Am J Rhinol. 2000;14(6):419–26.PubMedCrossRef Welkoborsky HJ, Gosepath J, Jacob R, et al. Biologic characteristics of paragangliomas of the nasal cavity and paranasal sinuses. Am J Rhinol. 2000;14(6):419–26.PubMedCrossRef
12.
go back to reference Ketabchi S, Massi D, Santoro R, Franchi A. Paraganglioma of the nasal cavity: a case report. Eur Arch Otorhinolaryngol. 2003;260(6):336–40.PubMedCrossRef Ketabchi S, Massi D, Santoro R, Franchi A. Paraganglioma of the nasal cavity: a case report. Eur Arch Otorhinolaryngol. 2003;260(6):336–40.PubMedCrossRef
13.
14.
go back to reference Apple D, Kreines K. Cushing’s syndrome due to ectopic ACTH production by a nasal paraganglioma. Am J Med Sci. 1982;283(1):32–5.PubMedCrossRef Apple D, Kreines K. Cushing’s syndrome due to ectopic ACTH production by a nasal paraganglioma. Am J Med Sci. 1982;283(1):32–5.PubMedCrossRef
15.
go back to reference Achilles E, Padberg BC, Holl K, Kloppel G, Schroder S. Immunocytochemistry of paragangliomas—value of staining for S-100 protein and glial fibrillary acidic protein in diagnosis and prognosis. Histopathology. 1991;18:453–8.PubMedCrossRef Achilles E, Padberg BC, Holl K, Kloppel G, Schroder S. Immunocytochemistry of paragangliomas—value of staining for S-100 protein and glial fibrillary acidic protein in diagnosis and prognosis. Histopathology. 1991;18:453–8.PubMedCrossRef
16.
go back to reference Thompson L. Head and neck pathology. A volume in the foundations in diagnostic pathology. Elsevier, Inc.; 2006. p. 124–154. Thompson L. Head and neck pathology. A volume in the foundations in diagnostic pathology. Elsevier, Inc.; 2006. p. 124–154.
17.
go back to reference Wenig B. Atlas of head and neck pathology. Elsevier, Inc.; 2008. p. 63–153. Wenig B. Atlas of head and neck pathology. Elsevier, Inc.; 2008. p. 63–153.
Metadata
Title
Hereditary Paraganglioma of the Nasopharynx
Authors
Nasser Said-Al-Naief
Junu Ojha
Publication date
01-12-2008
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 4/2008
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-008-0090-1

Other articles of this Issue 4/2008

Head and Neck Pathology 4/2008 Go to the issue

Sine qua none Radiology-Pathology

Parathyroid Adenoma