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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2008

01-09-2008 | Case Report

Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation

Authors: Fumio Ide, Kenji Mishima, Ichiro Saito

Published in: Head and Neck Pathology | Issue 3/2008

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Abstract

An unusual case of mucoepidermoid carcinoma (MEC) of intraoral minor salivary gland origin with spindled morphology was presented. A fascicular stream of bland spindle cells from typical MEC areas amounted to more than 70% of the tumor. Spindle population had features consistent with immunohistochemical and ultrastructural profiles of intermediate cells and lacked overexpression of p53 and cyclin D1. There was no difference in the Ki-67 index between two distinct components. Awareness of extensive spindle cell change replacing a significant portion of low-grade MEC is crucial to avoid an erroneous interpretation of dedifferentiated sarcomatoid transformation.
Literature
1.
Brandwein MS, Ivanov K, Wallace DI, et al. Mucoepidermoid carcinoma. A clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25:835–45.PubMedCrossRef
2.
3.
4.
Ide F, Obara K, Enatsu K, Mishima K, Saito I. Sclerosing mucoepidermoid carcinoma of the oral cavity. J Oral Pathol Med. 2005;34:187–9.PubMedCrossRef
5.
Lucas RB. Pathology of tumours of the oral tissues. London: Churchill; 1964. p. 228–32.
6.
Thackray AC, Lucas RB. Tumors of the major salivary glands. Washington DC: Armed Forces Institute of Pathology; 1974. p. 69–80.
7.
Love GL, Sarma DP. Spindle cell mucoepidermoid carcinoma of submandibular gland. J Surg Oncol. 1986;31:66–8.PubMedCrossRef
8.
Zarbo RJ. Salivary gland neoplasia: a review for the practicing pathologist. Mod Pathol. 2002;15:298–323.PubMedCrossRef
9.
Latham B, Dickersin GR, Oliva E. Subtypes of chromophobe cell renal carcinoma. An ultrastructural and histochemical study of 13 cases. Am J Surg Pathol. 1999;23:530–5.PubMedCrossRef
10.
Cheuk W, Chan JKC, Ngan RKC. Dedifferentiation in adenoid cystic carcinoma of salivary gland. An uncommon complication associated with an accelerated clinical course. Am J Surg Pathol. 1999;23:465–72.PubMedCrossRef
11.
Piana S, Cavazza A, Pedroni C, Scotti R, Serra L, Gardini G. Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features. Arch Pathol Lab Med. 2002;126:1104–5.PubMed
12.
Ide F, Mishima K, Saito I. Sarcomatoid salivary duct carcinoma of the oral cavity. Virchows Arch. 2003;443:686–9.PubMedCrossRef
13.
Ogawa I, Nishida T, Miyauchi M, Sato S, Takata T. Dedifferentiated malignant myoepithelioma of the parotid gland. Pathol Int. 2003;53:704–9.PubMedCrossRef
14.
Nagao T, Gaffey TA, Kay PA, et al. Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. Hum Pathol. 2003;34:1068–72.PubMedCrossRef
15.
Savera AT, Zarbo RJ. Defining the role of myoepithelium in salivary gland neoplasia. Adv Anat Pathol. 2004;11:69–85.PubMedCrossRef
16.
Chaudhry AP, Cutler LS, Liefer C, Labay G, Satchidanand S, Yamame GM. Ultrastructural study of the histogenesis of salivary gland mucoepidermoid carcinoma. J Oral Pathol Med. 1989;18:400–9.PubMedCrossRef
17.
Dardick I, Gliniecki MR, Heathcote JG, Buford-Mason A. Comparative histogenesis and morphogenesis of mucoepidermoid carcinoma and pleomorphic adenoma. An ultrastructural study. Virchows Arch A Pathol Anat. 1990;417:405–17.CrossRef
18.
Yook JI, Lee SA, Chun YC, Huh J, Cha IH, Kim J. The myoepithelial cell differentiation of mucoepidermoid carcinoma in a collagen gel-based coculture model. J Oral Pathol Med. 2004;33:237–42.PubMedCrossRef
19.
Nicolatou O, Harwick RD, Putong P, Leifer C. Ultrastructural characterization of intermediate cells of mucoepidermoid carcinoma of the parotid. Oral Surg Oral Med Oral Pathol. 1979;48:324–36.PubMedCrossRef
Metadata
Title
Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation
Authors
Fumio Ide
Kenji Mishima
Ichiro Saito
Publication date
01-09-2008
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 3/2008
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-008-0067-0

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