Skip to main content
Top
Published in: Head and Neck Pathology 2/2008

01-06-2008 | Symposia

Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract

Author: Bruce M. Wenig

Published in: Head and Neck Pathology | Issue 2/2008

Login to get access

Abstract

Intraoperative consultation (frozen section) plays an important part in the treatment of the head and neck cancer patient. The appropriate use of intraoperative consultations (frozen sections) usually results in a definitive diagnosis with immediate therapeutic impact while the patient is in the operating room. Among the determinations made by frozen section analysis include the evaluation of adequacy of surgical margins of resection; the differentiation between nonneoplastic, benign and malignant proliferations; the evaluation of lymph nodes for the presence of metastatic disease; the determination of specimen identification and specimen adequacy, including the verification of such organs as the parathyroid glands; and the determination of whether a given case requires special diagnostic testing best performed on frozen material, such as for lymphomas. This paper focuses on intraoperative consultation of mucosal lesions of the upper aerodigestive tract, including epithelial dysplasia and squamous cell carcinoma. Other issues that often not diagnosed or at issue at the time of surgery, including the diagnosis of microinvasive carcinoma and differentiating inflammatory lesions from neoplastic lesions are included for completion.
Literature
1.
go back to reference Dehner LP, Rosai J. Frozen section examination in surgical pathology. Minn Med. 1977;60:83–94.PubMed Dehner LP, Rosai J. Frozen section examination in surgical pathology. Minn Med. 1977;60:83–94.PubMed
2.
go back to reference Ferreiro JA, Myers JL, Bostwick DG. Accuracy of frozen section diagnosis in surgical pathology: review of 1-year experience with 24,880 cases at Mayo Clinic Rochester. Mayo Clin Proc. 1995;70:1137–41.PubMed Ferreiro JA, Myers JL, Bostwick DG. Accuracy of frozen section diagnosis in surgical pathology: review of 1-year experience with 24,880 cases at Mayo Clinic Rochester. Mayo Clin Proc. 1995;70:1137–41.PubMed
3.
go back to reference Holaday WJ, Assor D. Ten thousand consecutive frozen section. A retrospective study focusing on accuracy and quality control. Am J Clin Pathol. 1974;61:769–77.PubMed Holaday WJ, Assor D. Ten thousand consecutive frozen section. A retrospective study focusing on accuracy and quality control. Am J Clin Pathol. 1974;61:769–77.PubMed
4.
go back to reference Howanitz PJ, Hoffman GG, Zarbo RJ. The accuracy of frozen-section diagnosis in 34 hospitals. Arch Pathol Lab Med. 1990;114:355–9.PubMed Howanitz PJ, Hoffman GG, Zarbo RJ. The accuracy of frozen-section diagnosis in 34 hospitals. Arch Pathol Lab Med. 1990;114:355–9.PubMed
5.
go back to reference Kaufman Z, Lew S, Giffel B, Dinbar A. Frozen-section diagnosis in surgical pathology. A prospective analysis of 526 frozen sections. Cancer. 1986;57:377–9.PubMedCrossRef Kaufman Z, Lew S, Giffel B, Dinbar A. Frozen-section diagnosis in surgical pathology. A prospective analysis of 526 frozen sections. Cancer. 1986;57:377–9.PubMedCrossRef
6.
go back to reference Rogers C, Klatt EC, Chandrasoma P. Accuracy of frozen-section diagnosis in a teaching hospital. Arch Pathol Lab Med. 1987;111:514–7.PubMed Rogers C, Klatt EC, Chandrasoma P. Accuracy of frozen-section diagnosis in a teaching hospital. Arch Pathol Lab Med. 1987;111:514–7.PubMed
7.
go back to reference Saltzstein SL, Nahum AM. Frozen section diagnosis: accuracy and errors; uses and abuses. Laryngoscope. 1973;83:1128–43.PubMedCrossRef Saltzstein SL, Nahum AM. Frozen section diagnosis: accuracy and errors; uses and abuses. Laryngoscope. 1973;83:1128–43.PubMedCrossRef
8.
go back to reference Sawady J, Berner JJ, Siegler EE. Accuracy of and reason for frozen sections: a correlative, retrospective study. Hum Pathol. 1988;19:1019–23.PubMedCrossRef Sawady J, Berner JJ, Siegler EE. Accuracy of and reason for frozen sections: a correlative, retrospective study. Hum Pathol. 1988;19:1019–23.PubMedCrossRef
9.
go back to reference Zarbo RJ, Hoffman GG, Howanitz PJ. Interinstituional comparison of frozen-section consultation: a College of American Pathologists q-probe study of 79,647 consultations in 297 North American institutions. Arch Pathol Lab Med. 1991;115:1187–94.PubMed Zarbo RJ, Hoffman GG, Howanitz PJ. Interinstituional comparison of frozen-section consultation: a College of American Pathologists q-probe study of 79,647 consultations in 297 North American institutions. Arch Pathol Lab Med. 1991;115:1187–94.PubMed
10.
go back to reference Dinardo L, Lin J, Carageore L, Powers CN. Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery. Laryngoscope. 2000;110:1773–6.PubMedCrossRef Dinardo L, Lin J, Carageore L, Powers CN. Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery. Laryngoscope. 2000;110:1773–6.PubMedCrossRef
11.
go back to reference Gandour-Edwards R, Donald PJ, Wiese D. The accuracy and clinical utility of frozen section in head and neck surgery. Evidence at a university medical center. Head Neck. 1993;15:33–8.PubMedCrossRef Gandour-Edwards R, Donald PJ, Wiese D. The accuracy and clinical utility of frozen section in head and neck surgery. Evidence at a university medical center. Head Neck. 1993;15:33–8.PubMedCrossRef
12.
go back to reference Gandour-Edwards RF, Donald PJ, Lie JT. Clinical utility of intraoperative frozen section diagnosis in head and neck surgery. A quality assurance perspective. Head Neck. 1993;15:373–6.PubMedCrossRef Gandour-Edwards RF, Donald PJ, Lie JT. Clinical utility of intraoperative frozen section diagnosis in head and neck surgery. A quality assurance perspective. Head Neck. 1993;15:373–6.PubMedCrossRef
13.
go back to reference Ranchod M. Upper aserodigestive tract. In: Ranchod M (ed) Intraoperative consultations in surgical pathology: state of the art reviews. California Society of Pathologists; 1996, vol 3(2). p. 299–304. Ranchod M. Upper aserodigestive tract. In: Ranchod M (ed) Intraoperative consultations in surgical pathology: state of the art reviews. California Society of Pathologists; 1996, vol 3(2). p. 299–304.
14.
go back to reference Byers RM, Bland KL, Borlase B, Luna M. Prognostic and therapeutic value of frozen section determination in the surgical treatment of squamous carcinoma of the head and neck. Am J Surg. 1978;136:525–8.PubMedCrossRef Byers RM, Bland KL, Borlase B, Luna M. Prognostic and therapeutic value of frozen section determination in the surgical treatment of squamous carcinoma of the head and neck. Am J Surg. 1978;136:525–8.PubMedCrossRef
15.
go back to reference Bähr W, Stoll P. Intraoperative histological evaluation of tumor resection borders without prolonging surgery. Int J Oral Maxillofac Surg. 1992;21:90–1.PubMedCrossRef Bähr W, Stoll P. Intraoperative histological evaluation of tumor resection borders without prolonging surgery. Int J Oral Maxillofac Surg. 1992;21:90–1.PubMedCrossRef
16.
go back to reference Spiro RH, Guillamondegui O, Paulino AF, Huvos AG. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 1999;21:408–13.PubMedCrossRef Spiro RH, Guillamondegui O, Paulino AF, Huvos AG. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 1999;21:408–13.PubMedCrossRef
17.
go back to reference Cooley ML, Hoffman HT, Robinson RA. Discrepancies in frozen section mucosal margin tissue in laryngeal squamous cell carcinoma. Head Neck. 2002;24:262–7.PubMedCrossRef Cooley ML, Hoffman HT, Robinson RA. Discrepancies in frozen section mucosal margin tissue in laryngeal squamous cell carcinoma. Head Neck. 2002;24:262–7.PubMedCrossRef
18.
go back to reference Batsakis JG. Surgical excision margins: a pathologist’s perspective. Adv Anat Pathol 1999;6:140–8.PubMed Batsakis JG. Surgical excision margins: a pathologist’s perspective. Adv Anat Pathol 1999;6:140–8.PubMed
19.
go back to reference Barnes L. Diseases of the larynx, hypopharynx, and esophagus. In: Barnes L, editor. Surgical pathology of the head and neck. Second edition, revised and expanded. Marcel Dekker, Inc.; New York. 2001:127–237. Barnes L. Diseases of the larynx, hypopharynx, and esophagus. In: Barnes L, editor. Surgical pathology of the head and neck. Second edition, revised and expanded. Marcel Dekker, Inc.; New York. 2001:127–237.
20.
go back to reference Looser KG, Shah JP, Strong EW. The significance of “positive” margins in surgically resected epidermoid carcinomas. Head Neck Surg. 1978;1:107–11.PubMedCrossRef Looser KG, Shah JP, Strong EW. The significance of “positive” margins in surgically resected epidermoid carcinomas. Head Neck Surg. 1978;1:107–11.PubMedCrossRef
21.
go back to reference Mantravadi RV, Haas RE, Leibner EJ, Skolnik EM, Applebaum EL. Postoprative radiotherapy for persistent tumor at the surgical margin in head and neck cancers. Laryngoscope 1983;93:1337–40.PubMed Mantravadi RV, Haas RE, Leibner EJ, Skolnik EM, Applebaum EL. Postoprative radiotherapy for persistent tumor at the surgical margin in head and neck cancers. Laryngoscope 1983;93:1337–40.PubMed
22.
go back to reference Brandwein-Gensler M, Teixeira MS, Lewis CM, et al. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–78.PubMedCrossRef Brandwein-Gensler M, Teixeira MS, Lewis CM, et al. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–78.PubMedCrossRef
23.
go back to reference Jacobs JR, Ahmad K, Casiano R, et al. Implications of positive surgical margins. Laryngoscope. 1993;103:64–8.PubMedCrossRef Jacobs JR, Ahmad K, Casiano R, et al. Implications of positive surgical margins. Laryngoscope. 1993;103:64–8.PubMedCrossRef
24.
go back to reference Scholl P, Byers RM, Batsakis JG, et al. Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue. Prognostic and therapeutic implications. Am J Surg. 1986;152:354–60.PubMedCrossRef Scholl P, Byers RM, Batsakis JG, et al. Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue. Prognostic and therapeutic implications. Am J Surg. 1986;152:354–60.PubMedCrossRef
25.
go back to reference Loree TR, Strong EW. Significance of “positive” margins in oral squamous cell carcinoma. Am J Surg. 1990;160:410–4.PubMedCrossRef Loree TR, Strong EW. Significance of “positive” margins in oral squamous cell carcinoma. Am J Surg. 1990;160:410–4.PubMedCrossRef
26.
go back to reference Batsakis JG. Surgical margins in squamous cell carcinoma. Ann Otol Rhinol Laryngol 1988;97:213–4.PubMed Batsakis JG. Surgical margins in squamous cell carcinoma. Ann Otol Rhinol Laryngol 1988;97:213–4.PubMed
27.
go back to reference Beitler JJ, Smith RV, Silver CE, et al. Close or positive margins after surgical resection for head and neck cancer patient: the addition of brachytherapy improves local control. Int J Radiat Oncol Biol Phys. 1998;40:313–7.PubMed Beitler JJ, Smith RV, Silver CE, et al. Close or positive margins after surgical resection for head and neck cancer patient: the addition of brachytherapy improves local control. Int J Radiat Oncol Biol Phys. 1998;40:313–7.PubMed
28.
go back to reference van Es RJJ, Amerongen N, Slootweg PJ, Egyedi P. Resection margin as a predictor of recurrence at the primary site for T1 and T2 oral cancers. Evaluation of histopathologic variables. Arch Otolaryngol Head Neck Surg. 1996;122:521–5.PubMed van Es RJJ, Amerongen N, Slootweg PJ, Egyedi P. Resection margin as a predictor of recurrence at the primary site for T1 and T2 oral cancers. Evaluation of histopathologic variables. Arch Otolaryngol Head Neck Surg. 1996;122:521–5.PubMed
29.
go back to reference Bauer WC, Lesinski SG, Ogura JH. The significance of positive margins in hemilaryngectomy specimens. Laryngoscope. 1975;85:1–13.PubMedCrossRef Bauer WC, Lesinski SG, Ogura JH. The significance of positive margins in hemilaryngectomy specimens. Laryngoscope. 1975;85:1–13.PubMedCrossRef
30.
go back to reference McGregor AD, MacDonald DG. Routes of entry of squamous cell carcinoma to the mandible. Head Neck Surg. 1988;10:294–301.PubMedCrossRef McGregor AD, MacDonald DG. Routes of entry of squamous cell carcinoma to the mandible. Head Neck Surg. 1988;10:294–301.PubMedCrossRef
31.
go back to reference McGregor AD, MacDonald DG. Patterns of spread of squamous cell carcinoma within the mandible. Head Neck. 1989;11:457–61.PubMedCrossRef McGregor AD, MacDonald DG. Patterns of spread of squamous cell carcinoma within the mandible. Head Neck. 1989;11:457–61.PubMedCrossRef
32.
go back to reference Cleary KR, Batsakis JG. Oral squamous cell carcinoma and the mandible. Ann Otol Rhinol Laryngol. 1995;104:977–9.PubMed Cleary KR, Batsakis JG. Oral squamous cell carcinoma and the mandible. Ann Otol Rhinol Laryngol. 1995;104:977–9.PubMed
33.
go back to reference Weisman RA, Kimmelman CP. Bone scanning in the assessment of mandibular invasion by oral cavity carcinoma. Laryngoscope. 1982;92:1–4.PubMedCrossRef Weisman RA, Kimmelman CP. Bone scanning in the assessment of mandibular invasion by oral cavity carcinoma. Laryngoscope. 1982;92:1–4.PubMedCrossRef
34.
go back to reference Forest LA, Shuller DE, Lucas JG, Sullivan MI. Rapid analysis of mandibular margins. Laryngoscope. 1995;105:475–7.CrossRef Forest LA, Shuller DE, Lucas JG, Sullivan MI. Rapid analysis of mandibular margins. Laryngoscope. 1995;105:475–7.CrossRef
35.
go back to reference Dubner S, Heller KS. Local control of squamous cell carcinoma following marginal segmented mandibulectomy. Head Neck. 1993;15:29–32.PubMedCrossRef Dubner S, Heller KS. Local control of squamous cell carcinoma following marginal segmented mandibulectomy. Head Neck. 1993;15:29–32.PubMedCrossRef
36.
go back to reference Beaumont DG, Hains JD. Changes in surgical margins in vivo following resection and after fixation. Aust J Otolaryngol. 1992;1:51–2. Beaumont DG, Hains JD. Changes in surgical margins in vivo following resection and after fixation. Aust J Otolaryngol. 1992;1:51–2.
37.
go back to reference Johnson RE, Sigman JD, Funk GF, Robinson RA, Hoffman HT. Quantification of surgical margin shrinkage in the oral cavity. Head Neck. 1997;19:281–6.PubMedCrossRef Johnson RE, Sigman JD, Funk GF, Robinson RA, Hoffman HT. Quantification of surgical margin shrinkage in the oral cavity. Head Neck. 1997;19:281–6.PubMedCrossRef
38.
go back to reference Sondenaa K, Kjellvold KH. A prospective study of the length of the distal margin after low anterior resection for rectal cancer. Int J Colorectal Dis. 1990;5:103–5.PubMedCrossRef Sondenaa K, Kjellvold KH. A prospective study of the length of the distal margin after low anterior resection for rectal cancer. Int J Colorectal Dis. 1990;5:103–5.PubMedCrossRef
39.
go back to reference Goldstein NS, Soman A, Sacksner J. Disparate surgical margin lengths of colorectal resection specimens between in vivo and in vitro measurements. The effects of surgical resection and formalin fixation on organ shrinkage. Am J Clin Pathol. 1999;111:349–51.PubMed Goldstein NS, Soman A, Sacksner J. Disparate surgical margin lengths of colorectal resection specimens between in vivo and in vitro measurements. The effects of surgical resection and formalin fixation on organ shrinkage. Am J Clin Pathol. 1999;111:349–51.PubMed
40.
go back to reference Gardner ES, Sumner WT, Cook JL. Predictable tissue shrinkage during frozen section histopathologic processing for Mohs micrographic surgery. Dermatologic Surg. 2001;27:813–8.CrossRef Gardner ES, Sumner WT, Cook JL. Predictable tissue shrinkage during frozen section histopathologic processing for Mohs micrographic surgery. Dermatologic Surg. 2001;27:813–8.CrossRef
41.
go back to reference Silverman MK. Golomb FM, Kopf AW, et al. Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens. J Am Acad Dermatol. 2002;27:214–9. Silverman MK. Golomb FM, Kopf AW, et al. Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens. J Am Acad Dermatol. 2002;27:214–9.
42.
go back to reference Fajardo LF. Radiation injury. In: Barnes L, editors. Surgical pathology of the head and neck. Second edition, revised and expanded. Marcel Dekker, Inc.: New York; 2001. p. 2171–90. Fajardo LF. Radiation injury. In: Barnes L, editors. Surgical pathology of the head and neck. Second edition, revised and expanded. Marcel Dekker, Inc.: New York; 2001. p. 2171–90.
43.
go back to reference Matsusaka S, Nagareda T, Yamasaki H, et al. Immunohistochemical evaluation for intraoperative rapid pathological assessment of the gastric margin. World J Surg. 2003;27:715–8.PubMedCrossRef Matsusaka S, Nagareda T, Yamasaki H, et al. Immunohistochemical evaluation for intraoperative rapid pathological assessment of the gastric margin. World J Surg. 2003;27:715–8.PubMedCrossRef
44.
go back to reference Brennan JA, Mao L, Hruban RH, et al. Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. N Engl J Med. 1995;332:429–35.PubMedCrossRef Brennan JA, Mao L, Hruban RH, et al. Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. N Engl J Med. 1995;332:429–35.PubMedCrossRef
45.
go back to reference Ball VA, Righi PD, Tejada E, et al. P53 immunostaining of surgical margins as a predictor of local recurrence in squamous cell carcinoma of the oral cavity and oropharynx. Ear Nose Throat J. 1997;76:818–23.PubMed Ball VA, Righi PD, Tejada E, et al. P53 immunostaining of surgical margins as a predictor of local recurrence in squamous cell carcinoma of the oral cavity and oropharynx. Ear Nose Throat J. 1997;76:818–23.PubMed
46.
go back to reference Franklin S, Pho T, Abreo FW, et al. Detection of the protoncogene eIF4E in larynx and hypopharynx cancers. Arch Otolaryngol Head Neck Surg. 1999;125:177–82.PubMed Franklin S, Pho T, Abreo FW, et al. Detection of the protoncogene eIF4E in larynx and hypopharynx cancers. Arch Otolaryngol Head Neck Surg. 1999;125:177–82.PubMed
47.
go back to reference Ord RA, Aisner S. Accuracy of frozen sections in assessing margins in oral cancer resection. J Oral Maxillofac Surg. 1997;55:663–9.PubMedCrossRef Ord RA, Aisner S. Accuracy of frozen sections in assessing margins in oral cancer resection. J Oral Maxillofac Surg. 1997;55:663–9.PubMedCrossRef
48.
go back to reference Remsen KA, Lucente FE, Biller HF. Reliability of frozen section diagnosis in head and neck neoplasms. Laryngoscope. 1984;94:519–24.PubMedCrossRef Remsen KA, Lucente FE, Biller HF. Reliability of frozen section diagnosis in head and neck neoplasms. Laryngoscope. 1984;94:519–24.PubMedCrossRef
49.
go back to reference Gnepp DR. Frozen sections. In: Gnepp DR, editor. Pathology of the head and neck. New York: Churchill Livingstone; 1988. p. 1–24. Gnepp DR. Frozen sections. In: Gnepp DR, editor. Pathology of the head and neck. New York: Churchill Livingstone; 1988. p. 1–24.
50.
go back to reference Rassekh CH, Johnson JT, Myers EN. Accuracy of intraoperative staging of the N0 neck in squamous cell carcinoma. Laryngoscope. 1995;105:1334–6.PubMedCrossRef Rassekh CH, Johnson JT, Myers EN. Accuracy of intraoperative staging of the N0 neck in squamous cell carcinoma. Laryngoscope. 1995;105:1334–6.PubMedCrossRef
51.
go back to reference Manni JJ, van den Hoogen FJA. Supraomohyoid neck dissection with frozen section biopsy as a staging procedure in the clinically node-negative neck in carcinoma of the oral cavity. Am J Surg. 1991;162:373–6.PubMedCrossRef Manni JJ, van den Hoogen FJA. Supraomohyoid neck dissection with frozen section biopsy as a staging procedure in the clinically node-negative neck in carcinoma of the oral cavity. Am J Surg. 1991;162:373–6.PubMedCrossRef
52.
go back to reference Shoaib T, Soutar DS, MacDonald DG, et al. The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. Cancer 2001;91:2077–83.PubMedCrossRef Shoaib T, Soutar DS, MacDonald DG, et al. The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. Cancer 2001;91:2077–83.PubMedCrossRef
53.
go back to reference Pitman KT, Johnson JT, Brown ML, Myers EN. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Laryngoscope. 2002;112:2101–13.PubMedCrossRef Pitman KT, Johnson JT, Brown ML, Myers EN. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Laryngoscope. 2002;112:2101–13.PubMedCrossRef
54.
go back to reference Ross GL, Soutar DS, Shoaib T, et al. The ability of lymphoscintigraphy to direct sentinel node biopsy in the clinically N0 neck for patients with head and neck squamous cell carcinoma. Br J Radiol. 2002;75:950–8.PubMed Ross GL, Soutar DS, Shoaib T, et al. The ability of lymphoscintigraphy to direct sentinel node biopsy in the clinically N0 neck for patients with head and neck squamous cell carcinoma. Br J Radiol. 2002;75:950–8.PubMed
55.
go back to reference Asthana S, Deo SV, Shukla NK, et al. Intraoperative neck staging using sentinel node biopsy and imprint cytology in oral cancer. Head Neck. 2003;25:368–72.PubMedCrossRef Asthana S, Deo SV, Shukla NK, et al. Intraoperative neck staging using sentinel node biopsy and imprint cytology in oral cancer. Head Neck. 2003;25:368–72.PubMedCrossRef
56.
go back to reference Civantos FJ, Gomez C, Duque C, et al. Sentinel node biopsy in oral cavity cancer correlation with PET scan and immunohistochemistry. Head Neck. 2003;25:1–9.PubMedCrossRef Civantos FJ, Gomez C, Duque C, et al. Sentinel node biopsy in oral cavity cancer correlation with PET scan and immunohistochemistry. Head Neck. 2003;25:1–9.PubMedCrossRef
57.
go back to reference Loree TR. Sentinel lymph node biopsy for early stage clinical N0 squamous cell carcinoma of the oral cavity. Ann Surg Oncol. 2004;11:725–6.PubMedCrossRef Loree TR. Sentinel lymph node biopsy for early stage clinical N0 squamous cell carcinoma of the oral cavity. Ann Surg Oncol. 2004;11:725–6.PubMedCrossRef
Metadata
Title
Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract
Author
Bruce M. Wenig
Publication date
01-06-2008
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 2/2008
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-008-0053-6

Other articles of this Issue 2/2008

Head and Neck Pathology 2/2008 Go to the issue

Sine qua none Radiology-Pathology

Juvenile Hemangioma of the Parotid Gland