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01-03-2008 | Original Research

Detection of the Epstein–Barr Virus (EBV) by In situ Hybridization as Definitive Diagnosis of Hairy Leukoplakia

Authors: Paulo Henrique Braz-Silva, Nathalie Pepe Medeiros de Rezende, Karem Lopez Ortega, Raimunda Telma de Macedo Santos, Marina Helena Cury Gallottini de Magalhães

Published in: Head and Neck Pathology | Issue 1/2008

Abstract

Histopathological findings in cases of hairy leukoplakia (HL) are not exclusive to this lesion. A total of 36 tissue samples from patients previously diagnosed with HL based solely on morphological aspects were used in this study. Our purpose was to confirm the presence of Epstein–Barr virus (EBV) in these tissue samples by in situ hybridization (ISH), and to compare the detection of EBV with specific histopathological findings observed in each case. Among the 36 specimens, 80.55% were EBV positive, confirming the previous clinical and histhophatological diagnosis. None of the histopathological findings analyzed correlated with the presence or absence of EBV. This shows that a definitive diagnosis of HL cannot be established based on histopathological findings alone. Because there are many important implications on the establishment of definitive diagnosis of HL, the detection of EBV by ISH is obligatory.

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Title: Detection of the Epstein–Barr Virus (EBV) by In situ Hybridization as Definitive Diagnosis of Hairy Leukoplakia
Authors: Paulo Henrique Braz-Silva
Nathalie Pepe Medeiros de Rezende
Karem Lopez Ortega
Raimunda Telma de Macedo Santos
Marina Helena Cury Gallottini de Magalhães
Publication date: 01-03-2008
Publisher: Humana Press Inc
Published in: Head and Neck Pathology / Issue 1/2008
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-007-0039-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Detection of the Epstein–Barr Virus (EBV) by In situ Hybridization as Definitive Diagnosis of Hairy Leukoplakia

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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