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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 6/2019

01-06-2019 | Hemophilia | Original Article

Serum Sclerostin Level and Bone Mineral Density in Pediatric Hemophilic Arthropathy

Authors: Dalia M. E. El-Mikkawy, Mohja A. Elbadawy, Shereen M. Abd El-Ghany, Dalia Samaha

Published in: Indian Journal of Pediatrics | Issue 6/2019

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Abstract

Objective

To assess serum sclerostin levels in relation to severity of arthropathy and bone mineral density (BMD) in children with hemophilic arthropathy.

Methods

This cross-sectional study included 40 male children suffering from Hemophilia A, and 10 matched healthy controls. Assessment of factor VIII deficiency degree, frequency of bleeding, type of treatment, body mass index (BMI), disease severity using the Hemophilia Joint Health Score (HJHS) and lumbar spine (LS) Z score for bone mineral density (BMD) using dual-energy X-ray absorbiometry was done. Serum sclerostin levels were measured for all patients and controls.

Results

Significant difference of serum sclerostin levels between the patient and control groups with Mean ± SD (0.09 ± 0.07 ng/ml) and (0.04 ± 0.01 ng/ml) (P value = 0.028) respectively was found. Significant positive correlations between serum sclerostin levels and the patients’ age, and HJHS (P value <0.05) were found, while it had negative correlation with DEXA Z score, not reaching a significant value. LS-BMD-Z score levels ranged from (−4.5 to 1.2), with 15 patients with low BMD Z score (less than −2) representing 37.5% of total patients.

Conclusions

Serum sclerostin levels are elevated in hemophilic children denoting bone metabolism affection and correlates with increased age, and HJHS. Increased levels of serum sclerostin may identify hemophilic patients at high risk for developing osteoporosis.
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Metadata
Title
Serum Sclerostin Level and Bone Mineral Density in Pediatric Hemophilic Arthropathy
Authors
Dalia M. E. El-Mikkawy
Mohja A. Elbadawy
Shereen M. Abd El-Ghany
Dalia Samaha
Publication date
01-06-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 6/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-019-02855-1

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