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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 1/2019

01-02-2019 | Sleep Apnea | Original Article

Identifying Pathways Mediating Obstructive Sleep Apnea and Obesity in Indian Children

Authors: Giulia Lorenzoni, Danila Azzolina, Gulshan Sethi, Sanjay Manchanda, Dario Gregori, Achal Gulati, Ileana Baldi

Published in: Indian Journal of Pediatrics | Special Issue 1/2019

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Abstract

Objective

Overweight and obesity in children is associated with several metabolic and cardiovascular impairments, including obstructive sleep apnea (OSA). However, the causal pathway from OSA to obesity is not fully known yet. The aim of this study was to explore the association between OSA and obesity-related metabolic outcomes in obese Indian children.

Methods

An observational, cross-sectional study was conducted. Obese children referred to the Otorhinolaryngology Department at the Maulana Azad Medical College (New Delhi, India) for suspicion of OSA were consecutively enrolled. OSA was diagnosed by polysomnographic parameters. Homeostasis model assessment (HOMA) was calculated to measure insulin sensitivity and HOMA > 4.39 was considered as a threshold for insulin resistance. The association between various polysomnographic measures and HOMA, adiponectin and various urinary catecholamines was assessed.

Results

Complete polysomnographic parameters were available for 45 children; of these 29 were found to suffer from OSA. OSA children had significantly higher glucose concentrations compared to non-OSA ones (p value = 0.012) but no differences were found in insulin resistance and urinary catecholamines levels. Older age was significantly associated to lower levels of catecholamines. No significant associations were found between polysomnographic parameters and both HOMA and adiponectin. Only age was found to be significantly associated with HOMA (p = 0.03) and adiponectin (p = 0.01).

Conclusions

A better understanding of the role played by OSA on obese children’s metabolic functions is crucial to implement specific prevention strategies to reduce the public health burden of non-communicable diseases.
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Metadata
Title
Identifying Pathways Mediating Obstructive Sleep Apnea and Obesity in Indian Children
Authors
Giulia Lorenzoni
Danila Azzolina
Gulshan Sethi
Sanjay Manchanda
Dario Gregori
Achal Gulati
Ileana Baldi
Publication date
01-02-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue Special Issue 1/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-018-2828-4

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