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Published in: Indian Journal of Pediatrics 1/2019

01-01-2019 | Review Article

Pediatric Neurocysticercosis

Authors: Pratibha Singhi, Arushi Gahlot Saini

Published in: Indian Journal of Pediatrics | Issue 1/2019

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Abstract

Neurocysticercosis is the most common helminth infection of nervous system in humans caused by the encysted larvae of Taenia solium. It is a major cause of epilepsy in tropical areas and the most common cause of focal-onset seizures in North Indian children. Children with neurocysticercosis have pleomorphic manifestations depending on the location, number and viability of the cysts and host response. In endemic areas, neurocysticercosis should be clinically suspected in any child with recent-onset seizures, headache or focal motor deficits where there is no other suggestion of an underlying neurological disorder. Diagnosis of neurocysticercosis is essentially based on neuroimaging; visualization of a scolex is diagnostic. Management includes use of cysticidal drugs usually albendazole, which seems to be effective for lesion resolution and seizure remission, use of steroids and anti-epileptic drugs. Single lesions portend good prognosis with resolution of lesions in >60% of the cases within 6 mo and good seizure control. Prognosis is guarded in cysticercus encephalitis, racemose and extraparenchymal neurocysticercosis.
Literature
1.
go back to reference Relationship between epilepsy and tropical diseases. Commission on tropical diseases of the international league against epilepsy. Epilepsia. 1994;35:89–93.CrossRef Relationship between epilepsy and tropical diseases. Commission on tropical diseases of the international league against epilepsy. Epilepsia. 1994;35:89–93.CrossRef
2.
go back to reference Singhi P, Ray M, Singhi S, Khandelwal N. Clinical spectrum of 500 children with neurocysticercosis and response to albendazole therapy. J Child Neurol. 2000;15:207–13.PubMedCrossRef Singhi P, Ray M, Singhi S, Khandelwal N. Clinical spectrum of 500 children with neurocysticercosis and response to albendazole therapy. J Child Neurol. 2000;15:207–13.PubMedCrossRef
3.
go back to reference Ndimubanzi PC, Carabin H, Budke CM, et al. A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Negl Trop Dis. 2010;4:e870.PubMedPubMedCentralCrossRef Ndimubanzi PC, Carabin H, Budke CM, et al. A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Negl Trop Dis. 2010;4:e870.PubMedPubMedCentralCrossRef
4.
go back to reference WHO. Accelerating work to overcome the global impact of neglected tropical diseases. A roadmap for impementation. Switzerland: World Health Organization; 2012. WHO. Accelerating work to overcome the global impact of neglected tropical diseases. A roadmap for impementation. Switzerland: World Health Organization; 2012.
5.
go back to reference Del Brutto OH, Garcia HH. Neurocysticercosis in nonendemic countries: time for a reappraisal. Neuroepidemiology. 2012;39:145–6.PubMedCrossRef Del Brutto OH, Garcia HH. Neurocysticercosis in nonendemic countries: time for a reappraisal. Neuroepidemiology. 2012;39:145–6.PubMedCrossRef
7.
go back to reference Mafojane NA, Appleton CC, Krecek RC, Michael LM, Willingham AL 3rd. The current status of neurocysticercosis in eastern and southern Africa. Acta Trop. 2003;87:25–33.PubMedCrossRef Mafojane NA, Appleton CC, Krecek RC, Michael LM, Willingham AL 3rd. The current status of neurocysticercosis in eastern and southern Africa. Acta Trop. 2003;87:25–33.PubMedCrossRef
9.
go back to reference Montano SM, Villaran MV, Ylquimiche L, et al. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology. 2005;65:229–33.PubMedCrossRef Montano SM, Villaran MV, Ylquimiche L, et al. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology. 2005;65:229–33.PubMedCrossRef
10.
go back to reference Medina MT, Aguilar-Estrada RL, Alvarez A, et al. Reduction in rate of epilepsy from neurocysticercosis by community interventions: the Salama, Honduras study. Epilepsia. 2011;52:1177–85. Medina MT, Aguilar-Estrada RL, Alvarez A, et al. Reduction in rate of epilepsy from neurocysticercosis by community interventions: the Salama, Honduras study. Epilepsia. 2011;52:1177–85.
11.
go back to reference Fleury A, Hernandez M, Fragoso G, Parkhouse RM, Harrison LJ, Sciutto E. Detection of secreted cysticercal antigen: a useful tool in the diagnosis of inflammatory neurocysticercosis. Trans R Soc Trop Med Hyg. 2003;97:542–6.PubMedCrossRef Fleury A, Hernandez M, Fragoso G, Parkhouse RM, Harrison LJ, Sciutto E. Detection of secreted cysticercal antigen: a useful tool in the diagnosis of inflammatory neurocysticercosis. Trans R Soc Trop Med Hyg. 2003;97:542–6.PubMedCrossRef
12.
go back to reference Khurana S, Aggarwal A, Malla N. Prevalence of anti-cysticercus antibodies in slum, rural and urban populations in and around union territory, Chandigarh. Indian J Pathol Microbiol. 2006;49:51–3.PubMed Khurana S, Aggarwal A, Malla N. Prevalence of anti-cysticercus antibodies in slum, rural and urban populations in and around union territory, Chandigarh. Indian J Pathol Microbiol. 2006;49:51–3.PubMed
13.
go back to reference Sahu PS, Patro S, Jena PK, Swain SK, Das BK. Imaging and serological-evidence of neurocysticercosis among patients with seizures in Odisha, an unexplored eastern coastal province in India. J Clin Diagn Res. 2015;9:DC06–10.PubMedPubMedCentral Sahu PS, Patro S, Jena PK, Swain SK, Das BK. Imaging and serological-evidence of neurocysticercosis among patients with seizures in Odisha, an unexplored eastern coastal province in India. J Clin Diagn Res. 2015;9:DC06–10.PubMedPubMedCentral
14.
go back to reference Cherian A, Syam UK, Sreevidya D, et al. Low seroprevalence of systemic cysticercosis among patients with epilepsy in Kerala--South India. J Infect Public Health. 2014;7:271–6.PubMedCrossRef Cherian A, Syam UK, Sreevidya D, et al. Low seroprevalence of systemic cysticercosis among patients with epilepsy in Kerala--South India. J Infect Public Health. 2014;7:271–6.PubMedCrossRef
15.
go back to reference Parija SC, Balamurungan N, Sahu PS, Subbaiah SP. Cysticercus antibodies and antigens in serum from blood donors from Pondicherry, India. Rev Inst Med Trop Sao Paulo. 2005;47:227–30.PubMedCrossRef Parija SC, Balamurungan N, Sahu PS, Subbaiah SP. Cysticercus antibodies and antigens in serum from blood donors from Pondicherry, India. Rev Inst Med Trop Sao Paulo. 2005;47:227–30.PubMedCrossRef
16.
go back to reference Prasad KN, Prasad A, Gupta RK, et al. Neurocysticercosis in patients with active epilepsy from the pig farming community of Lucknow district, north India. Trans R Soc Trop Med Hyg. 2009;103:144–50.PubMedCrossRef Prasad KN, Prasad A, Gupta RK, et al. Neurocysticercosis in patients with active epilepsy from the pig farming community of Lucknow district, north India. Trans R Soc Trop Med Hyg. 2009;103:144–50.PubMedCrossRef
17.
go back to reference Prasad KN, Verma A, Srivastava S, Gupta RK, Pandey CM, Paliwal VK. An epidemiological study of asymptomatic neurocysticercosis in a pig farming community in northern India. Trans R Soc Trop Med Hyg. 2011;105:531–6.PubMedCrossRef Prasad KN, Verma A, Srivastava S, Gupta RK, Pandey CM, Paliwal VK. An epidemiological study of asymptomatic neurocysticercosis in a pig farming community in northern India. Trans R Soc Trop Med Hyg. 2011;105:531–6.PubMedCrossRef
18.
go back to reference Singh G, Bawa J, Chinna D, et al. Association between epilepsy and cysticercosis and toxocariasis: a population-based case-control study in a slum in India. Epilepsia. 2012;53:2203–8.PubMedCrossRef Singh G, Bawa J, Chinna D, et al. Association between epilepsy and cysticercosis and toxocariasis: a population-based case-control study in a slum in India. Epilepsia. 2012;53:2203–8.PubMedCrossRef
20.
go back to reference Ito A, Putra MI, Subahar R, et al. Dogs as alternative intermediate hosts of Taenia solium in Papua (Irian Jaya), Indonesia confirmed by highly specific ELISA and immunoblot using native and recombinant antigens and mitochondrial DNA analysis. J Helminthol. 2002;76:311–4.PubMedCrossRef Ito A, Putra MI, Subahar R, et al. Dogs as alternative intermediate hosts of Taenia solium in Papua (Irian Jaya), Indonesia confirmed by highly specific ELISA and immunoblot using native and recombinant antigens and mitochondrial DNA analysis. J Helminthol. 2002;76:311–4.PubMedCrossRef
21.
go back to reference Mahanty S, Garcia HH. Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. Prog Neurobiol. 2010;91:172–84.PubMedCrossRef Mahanty S, Garcia HH. Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. Prog Neurobiol. 2010;91:172–84.PubMedCrossRef
22.
go back to reference Alvarez JI, Rivera J, Teale JM. Differential release and phagocytosis of tegument glycoconjugates in neurocysticercosis: implications for immune evasion strategies. PLoS Negl Trop Dis. 2008;2:e218.PubMedPubMedCentralCrossRef Alvarez JI, Rivera J, Teale JM. Differential release and phagocytosis of tegument glycoconjugates in neurocysticercosis: implications for immune evasion strategies. PLoS Negl Trop Dis. 2008;2:e218.PubMedPubMedCentralCrossRef
23.
go back to reference Verma A, Prasad KN, Gupta RK, et al. Toll-like receptor 4 polymorphism and its association with symptomatic neurocysticercosis. J Infect Dis. 2010;202:1219–25.PubMedCrossRef Verma A, Prasad KN, Gupta RK, et al. Toll-like receptor 4 polymorphism and its association with symptomatic neurocysticercosis. J Infect Dis. 2010;202:1219–25.PubMedCrossRef
24.
go back to reference Cooke JC, Gelman JS, Harper RW. Echocardiologists' role in the deployment of the Amplatzer atrial septal occluder device in adults. J Am Soc Echocardiogr. 2001;14:588–94.PubMedCrossRef Cooke JC, Gelman JS, Harper RW. Echocardiologists' role in the deployment of the Amplatzer atrial septal occluder device in adults. J Am Soc Echocardiogr. 2001;14:588–94.PubMedCrossRef
25.
go back to reference Rathore C, Thomas B, Kesavadas C, Radhakrishnan K. Calcified neurocysticercosis lesions and hippocampal sclerosis: potential dual pathology? Epilepsia. 2012;53:e60–2.PubMedCrossRef Rathore C, Thomas B, Kesavadas C, Radhakrishnan K. Calcified neurocysticercosis lesions and hippocampal sclerosis: potential dual pathology? Epilepsia. 2012;53:e60–2.PubMedCrossRef
26.
go back to reference Morales NM, Agapejev S, Morales RR, Padula NA, Lima MM. Clinical aspects of neurocysticercosis in children. Pediatr Neurol. 2000;22:287–91.PubMedCrossRef Morales NM, Agapejev S, Morales RR, Padula NA, Lima MM. Clinical aspects of neurocysticercosis in children. Pediatr Neurol. 2000;22:287–91.PubMedCrossRef
27.
go back to reference Singhi P, Saini AG, Sankhyan N. Amaurosis fugax caused by neurocysticercosis. Pediatr Infect Dis J. 2014;33:427.PubMedCrossRef Singhi P, Saini AG, Sankhyan N. Amaurosis fugax caused by neurocysticercosis. Pediatr Infect Dis J. 2014;33:427.PubMedCrossRef
30.
go back to reference Singhi P, Saini AG. Pediatric neurocysticercosis: current challenges and future prospects. Pediatr Health Med Ther. 2016;7:5–16.CrossRef Singhi P, Saini AG. Pediatric neurocysticercosis: current challenges and future prospects. Pediatr Health Med Ther. 2016;7:5–16.CrossRef
31.
32.
go back to reference Del Brutto OH, Wadia NH, Dumas M, Cruz M, Tsang VC, Schantz PM. Proposal of diagnostic criteria for human cysticercosis and neurocysticercosis. J Neurol Sci. 1996;142:1–6.PubMedCrossRef Del Brutto OH, Wadia NH, Dumas M, Cruz M, Tsang VC, Schantz PM. Proposal of diagnostic criteria for human cysticercosis and neurocysticercosis. J Neurol Sci. 1996;142:1–6.PubMedCrossRef
34.
go back to reference Singhi PD, Baranwal AK. Single small enhancing computed tomographic lesion in Indian children--I: evolution of current concepts. J Trop Pediatr. 2001;47:204–7.PubMedCrossRef Singhi PD, Baranwal AK. Single small enhancing computed tomographic lesion in Indian children--I: evolution of current concepts. J Trop Pediatr. 2001;47:204–7.PubMedCrossRef
35.
go back to reference do Amaral LL, Ferreira RM, da Rocha AJ, Ferreira NP. Neurocysticercosis: evaluation with advanced magnetic resonance techniques and atypical forms. Top Magn Reson Imaging. 2005;16:127–44.PubMedCrossRef do Amaral LL, Ferreira RM, da Rocha AJ, Ferreira NP. Neurocysticercosis: evaluation with advanced magnetic resonance techniques and atypical forms. Top Magn Reson Imaging. 2005;16:127–44.PubMedCrossRef
36.
go back to reference Singhi PD, Baranwal AK. Single small enhancing computed tomographic lesions in indian children--II. Clinical features, pathology, radiology and management. J Trop Pediatr. 2001;47:266–70.PubMedCrossRef Singhi PD, Baranwal AK. Single small enhancing computed tomographic lesions in indian children--II. Clinical features, pathology, radiology and management. J Trop Pediatr. 2001;47:266–70.PubMedCrossRef
37.
go back to reference Pretell EJ, Martinot C Jr, Garcia HH, Alvarado M, Bustos JA, Martinot C. Differential diagnosis between cerebral tuberculosis and neurocysticercosis by magnetic resonance spectroscopy. J Comput Assist Tomogr. 2005;29:112–4.PubMedCrossRef Pretell EJ, Martinot C Jr, Garcia HH, Alvarado M, Bustos JA, Martinot C. Differential diagnosis between cerebral tuberculosis and neurocysticercosis by magnetic resonance spectroscopy. J Comput Assist Tomogr. 2005;29:112–4.PubMedCrossRef
38.
go back to reference Rajshekhar V, Haran RP, Prakash GS, Chandy MJ. Differentiating solitary small cysticercus granulomas and tuberculomas in patients with epilepsy. Clinical and computerized tomographic criteria. J Neurosurg. 1993;78:402–7.PubMedCrossRef Rajshekhar V, Haran RP, Prakash GS, Chandy MJ. Differentiating solitary small cysticercus granulomas and tuberculomas in patients with epilepsy. Clinical and computerized tomographic criteria. J Neurosurg. 1993;78:402–7.PubMedCrossRef
39.
go back to reference Atluri SR, Singhi P, Khandelwal N, Malla N. Evaluation of excretory secretory and 10-30 kDa antigens of Taenia solium cysticerci by EITB assay for the diagnosis of neurocysticercosis. Parasite Immunol. 2009;31:151–5.PubMedCrossRef Atluri SR, Singhi P, Khandelwal N, Malla N. Evaluation of excretory secretory and 10-30 kDa antigens of Taenia solium cysticerci by EITB assay for the diagnosis of neurocysticercosis. Parasite Immunol. 2009;31:151–5.PubMedCrossRef
40.
go back to reference Sahu PS, Parija SC, Jayachandran S. Antibody specific to 43kDa excretory-secretory antigenic peptide of Taenia solium metacestode as a potential diagnostic marker in human neurocysticercosis. Acta Trop. 2010;115:257–61.PubMedCrossRef Sahu PS, Parija SC, Jayachandran S. Antibody specific to 43kDa excretory-secretory antigenic peptide of Taenia solium metacestode as a potential diagnostic marker in human neurocysticercosis. Acta Trop. 2010;115:257–61.PubMedCrossRef
41.
go back to reference Atluri SR, Singhi P, Khandelwal N, Malla N. Neurocysticercosis immunodiagnosis using Taenia solium cysticerci crude soluble extract, excretory secretory and lower molecular mass antigens in serum and urine samples of Indian children. Acta Trop. 2009;110:22–7.PubMedCrossRef Atluri SR, Singhi P, Khandelwal N, Malla N. Neurocysticercosis immunodiagnosis using Taenia solium cysticerci crude soluble extract, excretory secretory and lower molecular mass antigens in serum and urine samples of Indian children. Acta Trop. 2009;110:22–7.PubMedCrossRef
42.
go back to reference Sahu PS, Parija S, Kumar D, Jayachandran S, Narayan S. Comparative profile of circulating antigenic peptides in CSF, serum & urine from patients with neurocysticercosis diagnosed by immunoblotting. Parasite Immunol. 2014;36:509–21.PubMedCrossRef Sahu PS, Parija S, Kumar D, Jayachandran S, Narayan S. Comparative profile of circulating antigenic peptides in CSF, serum & urine from patients with neurocysticercosis diagnosed by immunoblotting. Parasite Immunol. 2014;36:509–21.PubMedCrossRef
43.
go back to reference Wilson M, Bryan RT, Fried JA, et al. Clinical evaluation of the cysticercosis enzyme-linked immunoelectrotransfer blot in patients with neurocysticercosis. J Infect Dis. 1991;164:1007–9.PubMedCrossRef Wilson M, Bryan RT, Fried JA, et al. Clinical evaluation of the cysticercosis enzyme-linked immunoelectrotransfer blot in patients with neurocysticercosis. J Infect Dis. 1991;164:1007–9.PubMedCrossRef
44.
go back to reference Mandal J, Singhi PD, Khandelwal N, Malla N. Evaluation of ELISA and dot blots for the serodiagnosis of neurocysticercosis, in children found to have single or multiple enhancing lesions in computerized tomographic scans of the brain. Ann Trop Med Parasitol. 2006;100:39–48.PubMedCrossRef Mandal J, Singhi PD, Khandelwal N, Malla N. Evaluation of ELISA and dot blots for the serodiagnosis of neurocysticercosis, in children found to have single or multiple enhancing lesions in computerized tomographic scans of the brain. Ann Trop Med Parasitol. 2006;100:39–48.PubMedCrossRef
45.
go back to reference Rodriguez S, Dorny P, Tsang VC, et al. Detection of Taenia solium antigens and anti-T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis. J Infect Dis. 2009;199:1345–52. Rodriguez S, Dorny P, Tsang VC, et al. Detection of Taenia solium antigens and anti-T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis. J Infect Dis. 2009;199:1345–52.
46.
go back to reference Noh J, Rodriguez S, Lee YM, et al. Recombinant protein- and synthetic peptide-based immunoblot test for diagnosis of neurocysticercosis. J Clin Microbiol. 2014;52:1429–34.PubMedPubMedCentralCrossRef Noh J, Rodriguez S, Lee YM, et al. Recombinant protein- and synthetic peptide-based immunoblot test for diagnosis of neurocysticercosis. J Clin Microbiol. 2014;52:1429–34.PubMedPubMedCentralCrossRef
47.
go back to reference Garcia HH, Gilman RH, Catacora M, Verastegui M, Gonzalez AE, Tsang VC. Serologic evolution of neurocysticercosis patients after antiparasitic therapy. Cysticercosis working group in Peru. J Infect Dis. 1997;175:486–9. Garcia HH, Gilman RH, Catacora M, Verastegui M, Gonzalez AE, Tsang VC. Serologic evolution of neurocysticercosis patients after antiparasitic therapy. Cysticercosis working group in Peru. J Infect Dis. 1997;175:486–9.
48.
go back to reference Camargo JA, Bertolucci PH. Quantification of Fas protein in CSF of patients with neurocysticercosis. Arq Neuropsiquiatr. 2012;70:262–6.PubMedCrossRef Camargo JA, Bertolucci PH. Quantification of Fas protein in CSF of patients with neurocysticercosis. Arq Neuropsiquiatr. 2012;70:262–6.PubMedCrossRef
49.
go back to reference Camargo JA, Bertolucci PH. Quantification of amino acid neurotransmitters in cerebrospinal fluid of patients with neurocysticercosis. Open Neurol J. 2015;9:15–20.PubMedPubMedCentralCrossRef Camargo JA, Bertolucci PH. Quantification of amino acid neurotransmitters in cerebrospinal fluid of patients with neurocysticercosis. Open Neurol J. 2015;9:15–20.PubMedPubMedCentralCrossRef
50.
go back to reference Otte WM, Singla M, Sander JW, Singh G. Drug therapy for solitary cysticercus granuloma: a systematic review and meta-analysis. Neurology. 2013;80:152–62.PubMedPubMedCentralCrossRef Otte WM, Singla M, Sander JW, Singh G. Drug therapy for solitary cysticercus granuloma: a systematic review and meta-analysis. Neurology. 2013;80:152–62.PubMedPubMedCentralCrossRef
51.
go back to reference Kaur S, Singhi P, Singhi S, Khandelwal N. Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J. 2009;28:403–6.PubMedCrossRef Kaur S, Singhi P, Singhi S, Khandelwal N. Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J. 2009;28:403–6.PubMedCrossRef
52.
go back to reference Baird RA, Wiebe S, Zunt JR, Halperin JJ, Gronseth G, Roos KL. Evidence-based guideline: treatment of parenchymal neurocysticercosis: report of the guideline development subcommittee of the American Academy of neurology. Neurology. 2013;80:1424–9.PubMedPubMedCentralCrossRef Baird RA, Wiebe S, Zunt JR, Halperin JJ, Gronseth G, Roos KL. Evidence-based guideline: treatment of parenchymal neurocysticercosis: report of the guideline development subcommittee of the American Academy of neurology. Neurology. 2013;80:1424–9.PubMedPubMedCentralCrossRef
53.
go back to reference Singhi P, Dayal D, Khandelwal N. One week versus four weeks of albendazole therapy for neurocysticercosis in children: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J. 2003;22:268–72.PubMed Singhi P, Dayal D, Khandelwal N. One week versus four weeks of albendazole therapy for neurocysticercosis in children: a randomized, placebo-controlled double blind trial. Pediatr Infect Dis J. 2003;22:268–72.PubMed
54.
55.
go back to reference Singhi P, Jain V, Khandelwal N. Corticosteroids versus albendazole for treatment of single small enhancing computed tomographic lesions in children with neurocysticercosis. J Child Neurol. 2004;19:323–7.PubMedCrossRef Singhi P, Jain V, Khandelwal N. Corticosteroids versus albendazole for treatment of single small enhancing computed tomographic lesions in children with neurocysticercosis. J Child Neurol. 2004;19:323–7.PubMedCrossRef
56.
go back to reference Singhi PD, Dinakaran J, Khandelwal N, Singhi SC. One vs. two years of anti-epileptic therapy in children with single small enhancing CT lesions. J Trop Pediatr. 2003;49:274–8.PubMedCrossRef Singhi PD, Dinakaran J, Khandelwal N, Singhi SC. One vs. two years of anti-epileptic therapy in children with single small enhancing CT lesions. J Trop Pediatr. 2003;49:274–8.PubMedCrossRef
59.
go back to reference Panic G, Duthaler U, Speich B, Keiser J. Repurposing drugs for the treatment and control of helminth infections. Int J Parasitol Drugs Drug Resist. 2014;4:185–200.PubMedPubMedCentralCrossRef Panic G, Duthaler U, Speich B, Keiser J. Repurposing drugs for the treatment and control of helminth infections. Int J Parasitol Drugs Drug Resist. 2014;4:185–200.PubMedPubMedCentralCrossRef
60.
go back to reference Devi R, Jain A, Hurkat P, Jain SK. Dual drug delivery using lactic acid conjugated SLN for effective management of neurocysticercosis. Pharm Res. 2015;32:3137–48.PubMedCrossRef Devi R, Jain A, Hurkat P, Jain SK. Dual drug delivery using lactic acid conjugated SLN for effective management of neurocysticercosis. Pharm Res. 2015;32:3137–48.PubMedCrossRef
Metadata
Title
Pediatric Neurocysticercosis
Authors
Pratibha Singhi
Arushi Gahlot Saini
Publication date
01-01-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 1/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-017-2460-8

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