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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 11/2016

01-11-2016 | Original Article

Comparison of Intranasal Dexmedetomidine with Intranasal Clonidine as a Premedication in Surgery

Authors: Gurkaran Kaur Sidhu, Seema Jindal, Gurpreet Kaur, Gurpreet Singh, Kewal Krishan Gupta, Shobha Aggarwal

Published in: Indian Journal of Pediatrics | Issue 11/2016

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Abstract

Objectives

To compare effectiveness of intranasal dexmedetomidine and clonidine as anxiolytics and sedatives in pediatric patients undergoing various surgeries.

Methods

This double blind randomized placebo controlled study was conducted on 105 surgical patients of American Society of Anesthesiologist (ASA) physical status І-ІІ, aged between 2 and 9 y in a tertiary-care hospital (February 2014 to September 2015). Participants were randomly allocated to three groups to receive either intranasal dexmedetomidine 2 μg/kg (Group І) or intranasal clonidine 3 μg/kg (Group ІІ) or intranasal saline 0.5 ml (Group ІІІ). The primary outcome measure was proportion of patients with satisfactory anxiolysis and sedation at 30 min after drug administration. Secondary outcome measures included time taken to achieve Aldrete score of 9 and number of doses of rescue analgesia required in 12 h after surgery.

Results

Satisfactory anxiolysis was achieved by 88.5% in Group І vs. 60% in Group ІІ (p = 0.001) and satisfactory sedation by 57.1% in Group І vs. 25.7% in Group ІІ (p = 0.001) 30 min after premedication. Rescue analgesia requirement was significantly less in Group І as compared to Group ІІ (p = 0.001) while time taken to achieve Aldrete score was comparable between the study groups (p = 0.185).

Conclusions

Intranasal dexmedetomidine is a better anxiolytic and sedative as compared to clonidine. Postoperative analgesic requirement was also significantly decreased after intranasal dexmedetomidine. Thus, it can be preferred as compared to clonidine for premedication in pediatric surgical patients.
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Metadata
Title
Comparison of Intranasal Dexmedetomidine with Intranasal Clonidine as a Premedication in Surgery
Authors
Gurkaran Kaur Sidhu
Seema Jindal
Gurpreet Kaur
Gurpreet Singh
Kewal Krishan Gupta
Shobha Aggarwal
Publication date
01-11-2016
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 11/2016
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-016-2149-4

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