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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 9/2014

01-09-2014 | Correspondence

5 α-Reductase Type 2 Deficiency — Response to Dihydrotestosterone Gel: Correspondence

Authors: Iram Shabir, Eunice Marumudi, Ram Kumar, Angela Ann Joseph, Madan L. Khurana, Manju Mehta, T. Satish Chandra, Ariachery C. Ammini

Published in: Indian Journal of Pediatrics | Issue 9/2014

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Excerpt

To The Editor: In the article by Madhavarao et al., recently published in Indian Journal of Pediatrics, the authors have described response to Dihydrotestosterone (DHT) gel in a case with 5 α-reductase 2 deficiency (5αRD). The child was put on three monthly intramuscular testosterone injections (25 mg), which increased the stretched penile length (SPL) to 2.1 cm from initial SPL of 1.3 cm and both the testes descended to labioscrotal folds with increase in rugosity. The authors also reported that the application of DHT gel increased SPL to 3 cm within 1 mo and later to 3.4 cm after 5 mo [1]. …
Literature
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2.
Praveen EP, Desai AK, Khurana ML, Philip J, Eunice M, Khadgawat R, et al. Gender identity of children and young adults with 5alpha-reductase deficiency. J Pediatr Endocrinol Metab. 2008;21:173–9.PubMedCrossRef
3.
Eunice M, Philibert P, Kulshreshtha B, Audran F, Paris F, Khurana ML, et al. Molecular diagnosis of 5α-reductase-2 gene mutation in two Indian families with male pseudohermaphroditism. Asian J Androl. 2008;10:815–8.PubMedCrossRef
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Nagaraja MR, Rastogi A, Raman R, Gupta DK, Singh SK. Molecular diagnosis of 46, XY DSD and identification of a novel 8 nucleotide deletion in exon 1 of the SRD5A2 gene. J Pediatr Endocrinol Metab. 2010;23:379–85.PubMedCrossRef
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Blanc T, Ayedi A, El-Ghoneimi A, Abdoul H, Aigrain Y, Paris F, et al. Testicular function and physical outcome in young adult males diagnosed with idiopathic 46, XY disorders of sex development during childhood. Eur J Endocrinol. 2011;165:907–15.PubMedCrossRef
Metadata
Title
5 α-Reductase Type 2 Deficiency — Response to Dihydrotestosterone Gel: Correspondence
Authors
Iram Shabir
Eunice Marumudi
Ram Kumar
Angela Ann Joseph
Madan L. Khurana
Manju Mehta
T. Satish Chandra
Ariachery C. Ammini
Publication date
01-09-2014
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 9/2014
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-013-1215-4

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