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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 1/2011

01-01-2011 | Clinical Brief

Case of TTP with Cerebral Infarct Secondary to Platelet Transfusion

Authors: Sushil P. Tripathi, Anand S. Deshpande, Sandhya Khadse, Rajesh K. Kulkarni

Published in: Indian Journal of Pediatrics | Issue 1/2011

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Abstract

Background

Thrombotic thrombocytopenic purpura (TTP) is a rare disease in children with significant mortality in cases who do not receive appropriate treatment.

Case

The author describe a 3-year-old child who presented with skin bleeds, microangiopathic anemia, thrombocytopenia and right sided hemi paresis with aphasia and altered sensorium following platelet transfusion.

Conclusion

A diagnosis of thrombotic thrombocytopenic purpura was made and the child recovered dramatically after giving fresh frozen plasma and steroids.
Literature
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Lawlor ER, Webb DW, Hill A, Wadsworth LD. Thrombotic hrombocytopenia: a treatablecause of childhood encephalopathy. J Pediatr. 1997;130:313–6.CrossRefPubMed
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Allford S, Machine S. Current understandingof the pathophysiology of thrombotic thrombocytopenic purpura. J Clin Pathol. 2000;53:313–7.CrossRef
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Tsai HM. Physiologic cleavage of vWF by a plasma protease dependent on its conformationand requires ion. Blood. 1996;87:4235–44.PubMed
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Bayer H. Plasmapheresis in thomobotic microangiopathy associated sndromes: review of outcome of data derived from clinicaltrials and open studies. Ther Apher. 2002;6:320–8.CrossRef
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Harkness DR, Byrnes JJ, Lian EC, Williams WD, Hensley GT. Hazard of platelet transfusion in thrombotic thrombocytopenic purpura. Semin Hematol. 1981;246:1931–3.
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Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med. 1991;325:393–7.CrossRefPubMed
Metadata
Title
Case of TTP with Cerebral Infarct Secondary to Platelet Transfusion
Authors
Sushil P. Tripathi
Anand S. Deshpande
Sandhya Khadse
Rajesh K. Kulkarni
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Indian Journal of Pediatrics / Issue 1/2011
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-010-0224-9

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