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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 2/2019

01-02-2019 | Research Article

Inter-observer variation of hippocampus delineation in hippocampal avoidance prophylactic cranial irradiation

Authors: F. Bartel, M. van Herk, H. Vrenken, F. Vandaele, S. Sunaert, K. de Jaeger, N. J. Dollekamp, C. Carbaat, E. Lamers, E. M. T. Dieleman, Y. Lievens, D. de Ruysscher, S. B. Schagen, M. B. de Ruiter, J. C. de Munck, J. Belderbos

Published in: Clinical and Translational Oncology | Issue 2/2019

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Abstract

Background

Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) techniques have been developed to reduce radiation damage to the hippocampus. An inter-observer hippocampus delineation analysis was performed and the influence of the delineation variability on dose to the hippocampus was studied.

Materials and methods

For five patients, seven observers delineated both hippocampi on brain MRI. The intra-class correlation (ICC) with absolute agreement and the generalized conformity index (CIgen) were computed. Median surfaces over all observers’ delineations were created for each patient and regional outlining differences were analysed. HA-PCI dose plans were made from the median surfaces and we investigated whether dose constraints in the hippocampus could be met for all delineations.

Results

The ICC for the left and right hippocampus was 0.56 and 0.69, respectively, while the CIgen ranged from 0.55 to 0.70. The posterior and anterior-medial hippocampal regions had most variation with SDs ranging from approximately 1 to 2.5 mm. The mean dose (Dmean) constraint was met for all delineations, but for the dose received by 1% of the hippocampal volume (D1%) violations were observed.

Conclusion

The relatively low ICC and CIgen indicate that delineation variability among observers for both left and right hippocampus was large. The posterior and anterior-medial border have the largest delineation inaccuracy. The hippocampus Dmean constraint was not violated.
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Metadata
Title
Inter-observer variation of hippocampus delineation in hippocampal avoidance prophylactic cranial irradiation
Authors
F. Bartel
M. van Herk
H. Vrenken
F. Vandaele
S. Sunaert
K. de Jaeger
N. J. Dollekamp
C. Carbaat
E. Lamers
E. M. T. Dieleman
Y. Lievens
D. de Ruysscher
S. B. Schagen
M. B. de Ruiter
J. C. de Munck
J. Belderbos
Publication date
01-02-2019
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 2/2019
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-018-1903-7

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