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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 5/2018

01-05-2018 | Review Article

Ki67 targeted strategies for cancer therapy

Authors: C. Yang, J. Zhang, M. Ding, K. Xu, L. Li, L. Mao, J. Zheng

Published in: Clinical and Translational Oncology | Issue 5/2018

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Abstract

Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous studies have indicated that Ki67 index independently predicts cancer progression. Moreover, because Ki67 is highly expressed in malignant cells but almost could not be detected in normal cells, it has become a promising target for cancer therapy. In this review, we summarize recent advances in Ki67 targeted cancer therapy. In particular, we highlight recent development on the exploitation of Ki67 promoter to drive the expression of siRNAs or therapeutic genes in cancer cells specifically. The use of Ki67 as an attractive target opens a new avenue for cancer therapy.
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Metadata
Title
Ki67 targeted strategies for cancer therapy
Authors
C. Yang
J. Zhang
M. Ding
K. Xu
L. Li
L. Mao
J. Zheng
Publication date
01-05-2018
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 5/2018
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-017-1774-3

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