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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 6/2017

01-06-2017 | Review Article

Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer

Authors: A. Valentino, P. Reclusa, R. Sirera, M. Giallombardo, C. Camps, P. Pauwels, S. Crispi, C. Rolfo

Published in: Clinical and Translational Oncology | Issue 6/2017

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Abstract

Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the required specificity. Clinical management of prostate cancer needs advances in the development of new non-invasive biomarkers, ameliorating current diagnosis and prognosis and guiding therapeutic decisions. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level. These miRNAs are expressed in the cells and are also present in cell-derived extracellular vesicles such as exosomes. Exosomes have been shown to act as mediators for cell to cell communication because of the regulatory functions of their content. High levels of exosomes are found in several body fluids from cancer patients and could be a potential source of non-invasive biomarkers. In this review, we summarize the diagnostic and prognostic utility of exosomal miRNAs in prostate cancer.
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Metadata
Title
Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer
Authors
A. Valentino
P. Reclusa
R. Sirera
M. Giallombardo
C. Camps
P. Pauwels
S. Crispi
C. Rolfo
Publication date
01-06-2017
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 6/2017
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-016-1599-5

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