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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 10/2015

01-10-2015 | Research Article

Sonographic features of primary tumor as independent predictive factors for lymph node metastasis in papillary thyroid carcinoma

Authors: Q. Wu, Y. Li, Y. Wang, B. Hu

Published in: Clinical and Translational Oncology | Issue 10/2015

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Abstract

Purpose

The aim of this research was to find the sonographic features of primary tumor as independent predictive factors for lymph node metastasis in papillary thyroid carcinoma.

Methods/patients

To facilitate the research, 514 patients with papillary thyroid carcinoma were divided into solitary and multifocal groups. In solitary group, thyroid lesions were divided into several subgroups by size, border, margin, echogenicity, echohomogeneity, calcification, vascularization, location, stiffness and Hashimoto’s thyroiditis (HT) conditions. Then, univariable and multivariable analyses were performed to find the sonographic features of primary tumor as independent predictive factors for lymph node metastasis in papillary thyroid carcinoma.

Results

A significant difference of lymph node metastasis rate was found between multifocal and solitary groups (P < 0.05). In univariable analysis, size, vascularization and coexistence of HT were found to be statistically significant factors (P = 0.004, 0.118, 0.016). Multivariable analysis revealed that lymph node metastasis rate was mainly associated with size [odds ratio (OR) = 1.690, 95 % confidence interval (CI) 1.157–2.469] and coexistence of HT (OR = 0.441, 95 % CI 0.219–0.888).

Conclusion

Preoperative sonographic features of primary tumor including the number, size and coexistence of HT were independent predictive factors for the state of cervical lymph node metastasis in patients with papillary thyroid carcinoma.
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Metadata
Title
Sonographic features of primary tumor as independent predictive factors for lymph node metastasis in papillary thyroid carcinoma
Authors
Q. Wu
Y. Li
Y. Wang
B. Hu
Publication date
01-10-2015
Publisher
Springer Milan
Published in
Clinical and Translational Oncology / Issue 10/2015
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-015-1313-z

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