Skip to main content
Top
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery 3/2019

01-11-2019 | Original Article

Conidiobolomycosis: An Unusual Fungal Disease—Our Experience

Authors: Sudip Kumar Das, Chiranjib Das, Amit Bikram Maity, Prasanta Kumar Maiti, Tapan Kanti Hazra, Saumendra Nath Bandyopadhyay

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Special Issue 3/2019

Login to get access

Abstract

Conidiobolomycosis is a rare mycotic disease caused by Conidiobolus coronatus. Very few cases have been reported in English literature. Often it is clinically misdiagnosed as soft tissue tumour. A prospective case study was done from 2006 to 2015 in a tertiary care hospital of West Bengal, India. The objectives of our study were to describe the epidemiological and clinical features and treatment of Conidiobolomycosis to prevent disfigurement. Patients clinically suspected to be suffering from Conidiobolomycosis were subjected to biopsy followed by histopathological and mycological examinations. Then they were treated with oral saturated solution of potassium iodide along with other drugs. Total six cases were histopathologically proved to be suffering from Conidiobolomycosis. Fungus was isolated and identified in one case. Complete resolution was seen in five patients. Conidiobolomycosis should be brought into mind as differential diagnosis of subcutaneous swelling in the rhinofacial region.
Literature
1.
go back to reference Ribes JA, Vanover-Sams CL, Baker DJ (2000) Zygomycetes in human disease. Clin Microbiol Rev 13(2):236–290CrossRef Ribes JA, Vanover-Sams CL, Baker DJ (2000) Zygomycetes in human disease. Clin Microbiol Rev 13(2):236–290CrossRef
2.
go back to reference Richardson MD, Warnock DW (2003) Entomophromycosis. In: Richardson MD, Warnock DW (eds) Fungal infection. Diagnosis and management, 3rd edn. Blackwell Publishing, Oxford), pp 293–297CrossRef Richardson MD, Warnock DW (2003) Entomophromycosis. In: Richardson MD, Warnock DW (eds) Fungal infection. Diagnosis and management, 3rd edn. Blackwell Publishing, Oxford), pp 293–297CrossRef
3.
go back to reference Chayakulkeeree M, Ghannoum MA, Perfeft JR (2006) Zygomycosis: the re-emerging fungal infection. Eur J Clin Microbiol Infect Dis 25:215–229CrossRef Chayakulkeeree M, Ghannoum MA, Perfeft JR (2006) Zygomycosis: the re-emerging fungal infection. Eur J Clin Microbiol Infect Dis 25:215–229CrossRef
4.
go back to reference Thotan SP, Kumar V, Gupta A, Mallya A, Rao S (2010) Subcutaneous phycomycosis-fungal infection mimicking a soft tissue tumor: a case report and review of literature. J Trop Pediatr 56(1):65–66CrossRef Thotan SP, Kumar V, Gupta A, Mallya A, Rao S (2010) Subcutaneous phycomycosis-fungal infection mimicking a soft tissue tumor: a case report and review of literature. J Trop Pediatr 56(1):65–66CrossRef
5.
go back to reference Sujatha S, Sheeladevi C, Khyriem AB, Parija SC, Thappa DM (2003) Subcuteneous zygomycosis caused by Basidiobolus ranarum—a case report. Indian J Med Microbiol 21(3):205–206PubMed Sujatha S, Sheeladevi C, Khyriem AB, Parija SC, Thappa DM (2003) Subcuteneous zygomycosis caused by Basidiobolus ranarum—a case report. Indian J Med Microbiol 21(3):205–206PubMed
6.
go back to reference Valle AC, Wanke B, Lazera MS, Monteiro PC, Veigas ML (2001) Entomophthoromycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole. Rev Inst Med Trop Sao Paulo 43:233–236CrossRef Valle AC, Wanke B, Lazera MS, Monteiro PC, Veigas ML (2001) Entomophthoromycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole. Rev Inst Med Trop Sao Paulo 43:233–236CrossRef
7.
go back to reference Shetty D, Rai S, Shetty S, Jagdish Chandra K, Kini H, Bhat S (2014) Rhinofacial zygomycosis—a rare and interesting case. Otolaryngol Online J 4(4):265–272 Shetty D, Rai S, Shetty S, Jagdish Chandra K, Kini H, Bhat S (2014) Rhinofacial zygomycosis—a rare and interesting case. Otolaryngol Online J 4(4):265–272
8.
go back to reference Thomas MM, Bal SM, Jayaprakash C, Jose P, Ebenezer R (2006) Rhinoentomophthoromycosis. Indian J Dermatol Venereol Leprol 72(4):296–299CrossRef Thomas MM, Bal SM, Jayaprakash C, Jose P, Ebenezer R (2006) Rhinoentomophthoromycosis. Indian J Dermatol Venereol Leprol 72(4):296–299CrossRef
9.
go back to reference Martinson FD, Clark BM (1967) Rhinophycomycosis entomophthorae in Nigeria. Am J Trop Med Hyg 16:40–47CrossRef Martinson FD, Clark BM (1967) Rhinophycomycosis entomophthorae in Nigeria. Am J Trop Med Hyg 16:40–47CrossRef
10.
go back to reference Boonsarngsuk V, Suankratay C, Wilde H (2001) Presumably entomophthoramycosis in a HIV-infected patient: the first in Thailand. J Med Assoc Thail 84:1635–1639 Boonsarngsuk V, Suankratay C, Wilde H (2001) Presumably entomophthoramycosis in a HIV-infected patient: the first in Thailand. J Med Assoc Thail 84:1635–1639
11.
go back to reference Walker SD, Clark RV, King CT, Humphries JE, Lytle LS, Butkus DE (1992) Fatal disseminated Conidiobolus coronatus infection in a renal transplant patient. Am J Clin Pathol 98:559–564CrossRef Walker SD, Clark RV, King CT, Humphries JE, Lytle LS, Butkus DE (1992) Fatal disseminated Conidiobolus coronatus infection in a renal transplant patient. Am J Clin Pathol 98:559–564CrossRef
12.
go back to reference Ochoa LF, Duque CS, Velez A (1996) Rhinoentomophthoromycosis—report of two cases. J Laryngol Otol 110:1154–1156CrossRef Ochoa LF, Duque CS, Velez A (1996) Rhinoentomophthoromycosis—report of two cases. J Laryngol Otol 110:1154–1156CrossRef
13.
go back to reference Mukhopadhyay D, Ghosh LM, Thammayya A, Sanyal M (1995) Entomophthoromycosis caused by Conidiobolus coronatus: clinicomycological study of a case. Auris Nasus Larynx 22(2):139–142CrossRef Mukhopadhyay D, Ghosh LM, Thammayya A, Sanyal M (1995) Entomophthoromycosis caused by Conidiobolus coronatus: clinicomycological study of a case. Auris Nasus Larynx 22(2):139–142CrossRef
14.
go back to reference Leopairut J, Larbcharoensub N, Cheewaruangroj W, Sungkanuparph S, Sathapatayavongs B (2014) Rhinofacial entomophthoramycosis; a case series and review of the literature. Southeast Asian J Trop Med Public Health 41(4):928–935 Leopairut J, Larbcharoensub N, Cheewaruangroj W, Sungkanuparph S, Sathapatayavongs B (2014) Rhinofacial entomophthoramycosis; a case series and review of the literature. Southeast Asian J Trop Med Public Health 41(4):928–935
15.
go back to reference Restrepo A (1994) Treatment of tropical mycoses. J Am Acad Dermatol 31:91–102CrossRef Restrepo A (1994) Treatment of tropical mycoses. J Am Acad Dermatol 31:91–102CrossRef
16.
go back to reference Bandeira V, Lascet IG (1995) Zigomicose. In: Talhari S, Neves RG (eds) Dermatologia tropical. Medsi, São Paulo, pp 191–202 Bandeira V, Lascet IG (1995) Zigomicose. In: Talhari S, Neves RG (eds) Dermatologia tropical. Medsi, São Paulo, pp 191–202
17.
go back to reference Ellis DH (1998) The zygomycetes. In: Ajello L, Hay RJ (eds) Medical mycology, 9th edn. Oxford University Press, New York, pp 247–276 (Collier L, Balows A, Sussman M Topley and Wilson’s microbiology and microbial infections v.4.) Ellis DH (1998) The zygomycetes. In: Ajello L, Hay RJ (eds) Medical mycology, 9th edn. Oxford University Press, New York, pp 247–276 (Collier L, Balows A, Sussman M Topley and Wilson’s microbiology and microbial infections v.4.)
18.
go back to reference Gilbert EF, Khoury GH, Pore RS (1970) Histopathological identification of entomophthora phycomycosis in deep mycotic infection in an infant. Arch Pathol 90:583–587PubMed Gilbert EF, Khoury GH, Pore RS (1970) Histopathological identification of entomophthora phycomycosis in deep mycotic infection in an infant. Arch Pathol 90:583–587PubMed
19.
go back to reference Hoogendijk CF, van Heerden WF, Pretorius E, Vismer HF, Jacobs JF (2006) Rhino-orbitocerebral entomophthoramycosis. Int J Oral Maxillofac Surg 35:277–280CrossRef Hoogendijk CF, van Heerden WF, Pretorius E, Vismer HF, Jacobs JF (2006) Rhino-orbitocerebral entomophthoramycosis. Int J Oral Maxillofac Surg 35:277–280CrossRef
20.
go back to reference Akpanonu BE, Ansel G, Karurich JD, Savolaine ER, Campbell EW, Myles JL (1991) Zygomycosis mimicking paranasal malignancy. Am J Trop Med Hyg 45:390–398CrossRef Akpanonu BE, Ansel G, Karurich JD, Savolaine ER, Campbell EW, Myles JL (1991) Zygomycosis mimicking paranasal malignancy. Am J Trop Med Hyg 45:390–398CrossRef
21.
go back to reference Balraj A, Anandi V, Raman R (1991) Rhinofacial conidiobolomycosis. Ear Nose Throat J 70:737–739PubMed Balraj A, Anandi V, Raman R (1991) Rhinofacial conidiobolomycosis. Ear Nose Throat J 70:737–739PubMed
22.
go back to reference Rippon JW et al (1982) Medical mycology, 2nd edn. W. B. Saunders Co, Philadelphia Rippon JW et al (1982) Medical mycology, 2nd edn. W. B. Saunders Co, Philadelphia
23.
go back to reference Chandler FW, Watts JC (1996) Fungal diseases. In: Damjanov I, Linder J (eds) Anderson's pathology. 10th edn. St. Louis, C.V. Mosby Company, MO, pp 951–984 Chandler FW, Watts JC (1996) Fungal diseases. In: Damjanov I, Linder J (eds) Anderson's pathology. 10th edn. St. Louis, C.V. Mosby Company, MO, pp 951–984
24.
go back to reference Ellis DH (2005) Systemic Zygomycetes-Mucormycosis. In: Merz WG, Hay RJ (ed) Topley and Wilson’s Microbiology and Microbial Infections, Medical Mycology, 10th edn. Hodder Arnold, London, pp 659–686 Ellis DH (2005) Systemic Zygomycetes-Mucormycosis. In: Merz WG, Hay RJ (ed) Topley and Wilson’s Microbiology and Microbial Infections, Medical Mycology, 10th edn. Hodder Arnold, London, pp 659–686
25.
go back to reference Prabhu RM, Patel R (2004) Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 10(suppl 1):31–47CrossRef Prabhu RM, Patel R (2004) Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 10(suppl 1):31–47CrossRef
26.
go back to reference Sugar AM (2005) Agents of mucormycosis and related species. In: Mandell GL, Bennett JE, Dolin R (eds) Mandell, Douglas, and Bennett’s principles and practice of infectious diseases, vol 2, 6th edn. Churchill Livingstone, Philadelphia, pp 2980–2981 Sugar AM (2005) Agents of mucormycosis and related species. In: Mandell GL, Bennett JE, Dolin R (eds) Mandell, Douglas, and Bennett’s principles and practice of infectious diseases, vol 2, 6th edn. Churchill Livingstone, Philadelphia, pp 2980–2981
27.
go back to reference Loreetta SD (2001) Newer uses of older drugs: an update. In: Stephen EW (ed) Comprehensive dermatologic drug therapy, 1st edn. WB Saunders Company, Philadelphia, pp 426–444 Loreetta SD (2001) Newer uses of older drugs: an update. In: Stephen EW (ed) Comprehensive dermatologic drug therapy, 1st edn. WB Saunders Company, Philadelphia, pp 426–444
28.
go back to reference Ramesh A, Deka RC, Vijayaraghavan M, Ray R, Kabra SK, Rakesh K, Manoj K (2000) Entomophthoromycosis of the nose and paranasal sinus. Indian J Pediatr 67(4):307–310CrossRef Ramesh A, Deka RC, Vijayaraghavan M, Ray R, Kabra SK, Rakesh K, Manoj K (2000) Entomophthoromycosis of the nose and paranasal sinus. Indian J Pediatr 67(4):307–310CrossRef
29.
go back to reference Haruna K, Shiraki Y, Hiruma M, Ikeda S, Kawasaki M (2006) A case of lymphangitic sporotrichosis occurring on both forearms with a published work review of cases of bilateral sporotrichosis in Japan. J Dermatol 33(5):364–367CrossRef Haruna K, Shiraki Y, Hiruma M, Ikeda S, Kawasaki M (2006) A case of lymphangitic sporotrichosis occurring on both forearms with a published work review of cases of bilateral sporotrichosis in Japan. J Dermatol 33(5):364–367CrossRef
30.
go back to reference Thomas PA (2003) Current perspectives on ophthalmic mycoses. Clin Microbiol Rev 16(4):730–797CrossRef Thomas PA (2003) Current perspectives on ophthalmic mycoses. Clin Microbiol Rev 16(4):730–797CrossRef
31.
go back to reference Maiti PK, Bandyopahyay D (1999) Case of entomophthoromycosis refractory to conventional therapy. Indian J Med Microbiol 17(3):150–151 Maiti PK, Bandyopahyay D (1999) Case of entomophthoromycosis refractory to conventional therapy. Indian J Med Microbiol 17(3):150–151
Metadata
Title
Conidiobolomycosis: An Unusual Fungal Disease—Our Experience
Authors
Sudip Kumar Das
Chiranjib Das
Amit Bikram Maity
Prasanta Kumar Maiti
Tapan Kanti Hazra
Saumendra Nath Bandyopadhyay
Publication date
01-11-2019
Publisher
Springer India
Published in
Indian Journal of Otolaryngology and Head & Neck Surgery / Issue Special Issue 3/2019
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-017-1182-6

Other articles of this Special Issue 3/2019

Indian Journal of Otolaryngology and Head & Neck Surgery 3/2019 Go to the issue