Top

Indian Journal of Otolaryngology and Head & Neck Surgery

Published in:

01-04-2011 | Main Article

Clinical Manifestations and Role of Proton Pump Inhibitors in the Management of Laryngopharyngeal Reflux

Authors: Suhail Amin Patigaroo, S. F. Hashmi, Syed Abrar Hasan, M. R. Ajmal, Nazia Mehfooz

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Issue 2/2011

Abstract

Laryngopharyngeal reflux (LPR) refers to the backflow of stomach contents into the throat that is into the hypopharynx. LPR is different from classical Gastroesophageal reflux disease (GERD) in many ways. Proton pump inhibitors have become the treatment of choice even though conflicting results exists in their response. Treatment requires acid suppression to be as complete as possible and treatment failure is not uncommon. In this article we present here our prospective study of 50 patients diagnosed as a case of LPR on the basis of reflux finding score and reflux symptom index. We tried to evaluate the role of PPI in LPR management by observing the effect of PPI on reflux finding score (RFS) and reflux symptom index (RFI) during the follow up period of 16 weeks.

Koufman JA, Aviv JE, Casiano RR (2002) Laryngopharyngeal reflux; position statement of the committe on speech, voice, and swallowing disorders of the American academy of otolaryngology-head and neck surgery. Otolaryngol Head Neck Surg 127(1):32–35PubMedCrossRef

Koufman JA (1991) The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24 hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development laryngeal injury. Laryngoscope 101(suppl 52):1–78PubMed

Koufman JA, Amin MR, Panetti M (2000) Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 123:385–388PubMedCrossRef

Koufman JA, Weiner GJ, Wallace CW (1988) Reflux laryngitis and its sequelae; the diagnostic role of ambulatory 24 hour pH monitoring. J Voice 2:78–79CrossRef

Vaezi MF, Hicks DM, Abelson TI (2003) Laryngeal signs and symptoms and GERD: a critical assessment of cause and effect association. Clin Gastroenterol Hepatol 1:333–344PubMedCrossRef

Belfasky PC, Postma GN, Koufman JA (2002) The association between laryngeal pseudo sulcus and laryngopharyngeal reflux. In: American Academy of otolaryngology Head and Neck surgery Foundation, Denver, 2002

Sen P, Georgalas C (2005) A systematic review of the role of the proton pump inhibitors for symptoms of laryngo-pharyngeal reflux. Clin Otolaryngol 31:20–24CrossRef

Delgaudio JM, Waring P (2003) Empiric esomeprazole in the treatment of laryngopharyngeal reflux. Laryngoscope 113:598–601PubMedCrossRef

Belfasky PC, Postma GN (2001) The validity and reliability of reflux finding score. The laryngoscope 111:1313–1317CrossRef

10.

Belafsky PC, Postma GN, Koufman JA (2002) Validity and reliability of the reflux symptom index. J Voice 16:274–277PubMedCrossRef

11.

Mesallam TA, Stemple JC (2007) Reflux symptom index versus reflux fining score. Ann Otol Rhinol Laryngol 116:436–440PubMed

12.

Kasper DL (2004) Harrison’s Principles of Internal Medicine, 16th edn. McGraw-Hill, Berkshire

13.

Delahunty JE, Cherry J (1968) Experimentally produced vocal cord granulomas. Laryngoscope 78:1941–1947PubMedCrossRef

14.

Wiener GJ, Cooper JB, Wu WC, Koufman JA, Richter JE (1986) Is hoarseness an atypical manifestation of gastroesophageal reflux (GER)? An ambulatory 24 hour pH study. Gastroenterology 90:A1691

15.

Koufman R, Toohil SR (1997) Consencus conference report. J Voice 10(3):215–216CrossRef

16.

Jecker P, Orloff LA et al (2005) Extraesophageal reflux and upper aero-digestive tract diseases. ORL 67:185–191PubMedCrossRef

17.

Mamede RC, De Mello-Filho FV, Vigario LC, Dantas RO (2000) Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. Otolaryngol Head Neck Surg 122:607–610PubMedCrossRef

18.

Bilgen C, Ogut F (2003) The comparison of empiric proton pump inhibitor trial versus 24 hour double probe Ph monitoring in laryngopharyngeal reflux. J Laryngo Otol 117:386–390

19.

Issing WJ, Karkos PD (2004) Dual probe 24 hour ambulatory pH monitoring for diagnosis of laryngopharyngeal reflux. J Laryngol Otol 118:845–848PubMedCrossRef

20.

Toros SZ, Toros AB (2008) Association of laryngopharyngeal manifestation and gastroesophageal reflux. Eur Arch Otorhinolaryngol 266(3):403–409PubMedCrossRef

21.

Karkos PD, Yates PD (2007) Is laryngo-pharyngeal reflux related to functional dysphonia. Ann Otol Rhinol Laryngol 116(1):24–29PubMed

22.

Pieter Noordzij J, Khidir A (2002) Correlation of pH probe measured laryngopharyngeal reflux with symptoms and signs of reflux laryngitis. The Laryngoscope 112(12):2192–2195PubMedCrossRef

23.

Thomas R, Eubanks DO, Pablo E, Omelanczuk MD (2001) Pharyngeal pH monitoring in 222 with suspected laryngeal reflux. J Gastrointestinal Surg 5(2):183–191CrossRef

24.

Book DT, Rhee JS (2002) Perspectives in laryngo-pharyngeal reflux: an international survey. Laryngoscope 112:1399–1406PubMedCrossRef

25.

Tezer MS, Kockar MC (2006) Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and helicobacter pylori expression. Acta Otolaryngol 126:958–961PubMedCrossRef

26.

Kamel PL, Hanson D (1994) Omeprazole for the treatment of posterior laryngitis. Am J Med 96:321–326PubMedCrossRef

27.

Amin MR, Postma G (2001) Proton pump resistance in the treatment of laryngopharyngeal reflux. Am J Otolaryngol Head Neck Surg 125(4):374–378CrossRef

28.

Jasperson D, Weber R (1996) Effect of omeprazole on the course of associated esophagitis and laryngitis. J Gastroenterol 31:765–767CrossRef

29.

Wo JM, Hunter JG (1997) Dual-channel ambulatory pH monitoring—a useful diagnostic tool. Dig Dis Sci 42:2222–2226PubMedCrossRef

30.

Hanson DG, Kamel PL et al (1995) Outcomes of anti-reflux therapy for the treatment of chronic laryngitis. Ann Otol Rhinol Laryngol 104:550–555PubMed

31.

Metz DC, Childs ML (1997) Pilot study of the oral omeprazole test for reflux laryngitis. Otol Laryngol Head Neck Surg 116:41–46CrossRef

32.

Shaw GY, Searl JP (1997) Laryngeal manifestations of gastroesophageal reflux before and after treatment with omeprazole. South Med J 90:1115–1122PubMedCrossRef

33.

Tauber S, Gross M (2002) Association of laryngopharyngeal symptoms with gastroesophageal reflux disease. Laryngoscope 112(5):879–886PubMedCrossRef

34.

Williams RB, Szczesniak MM (2004) Predictors of outcome in an open label, therapeutic trial of high dose omeprazole in laryngitis. Am J Gastroenterol 99:777–785PubMedCrossRef

35.

Eherer AJ, Habermann W (2003) Effect of pantoprazole on the course of reflux associated laryngitis: a placebo controlled double blind crossover study. Scand J Gastroenterol 38:462–467PubMedCrossRef

36.

Wo JM, Koopman J (2006) Double-blind placebo control trial with single dose pantoprazole for laryngopharyngeal reflux. Am J Gastroenterol 101:1972–1978PubMedCrossRef

37.

Steward DL, Wilson KM, Kelly DH et al (2004) Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. Otolaryngol Head Neck Surg 131:342–350PubMedCrossRef

Title: Clinical Manifestations and Role of Proton Pump Inhibitors in the Management of Laryngopharyngeal Reflux
Authors: Suhail Amin Patigaroo
S. F. Hashmi
Syed Abrar Hasan
M. R. Ajmal
Nazia Mehfooz
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery / Issue 2/2011
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-011-0253-3

At a glance: The STEP trials

Springer Medicine

Clinical Manifestations and Role of Proton Pump Inhibitors in the Management of Laryngopharyngeal Reflux

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2011

Skin Prick Testing and Immunotherapy in Nasobronchial Allergy: Our Experience

Comparing the Efficacy of Alkaline Nasal Douches Versus Decongestant Nasal Drops in Postoperative Care After Septal Surgery: A Randomised Single Blinded Clinical Pilot Study

Head and Neck Teratomas in Children: A Case Series

Analysis of Lower Airway Inflammation in a Rabbit Model of Acute Rhinosinusitis

Intelligibility and Acoustic Characteristics of Clear and Conversational Speech in Telugu (A South Indian Dravidian Language)

Endoscopic Management of Posterior Epistaxis