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Indian Journal of Thoracic and Cardiovascular Surgery

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Open Access 03-12-2022 | Aortic Valve Replacement | Original Article

Long-term evaluation of TTK Chitra™ heart valve prosthesis — a retrospective-prospective cohort study

Authors: Praveen Kerala Varma, Maniyal Vijayakumar, Gopichettipalayam Subbaratnam Bhuvaneshwar, Adarsh Syla Kumar, Neethu Krishna

Published in: Indian Journal of Thoracic and Cardiovascular Surgery | Issue 1/2023

Abstract

Purpose

The TTK Chitra™ heart valve has more than 1,40,000 implantations so far, but no long-term data has been published. This study aims to provide long-term results of the valve.

Methodology

A cohort of 476 patients with implantations from January 2006 to December 2018 were followed up prospectively consisting of 104 aortic valve replacement (AVR), 87 double valve replacement (DVR), and 285 mitral valve replacement (MVR) patients. Total follow-up was 4079 patient-years (py) (AVR = 983, MVR = 2392, DVR = 704), being 96% complete.

Results

The results showed that actuarial survival at 15 years was 82.3% for AVR, 60.7% for MVR, and 52.2% for DVR. Freedom from all valve-related mortality and morbidity at 15 years was 73.8%, 64.8%, and 61.9% for AVR, MVR, and DVR, respectively. There was one instance of structural failure of valve disc leading to severe valvar regurgitation. Valve thrombosis incidence was 1 in AVR (0.1%/py), 6 in MVR (0.25%/py), and 1 in DVR (0.14%/py). Thrombo-embolic episodes occurred in 50 patients (AVR = 7 patients at 0.7%/py; MVR = 36 patients at 1.5%/py; DVR = 7 patients at 0.99%/py) and major hemorrhage (bleeding) in 24 patients (AVR = 0.61%/py; MVR = 0.5%/py; and DVR = 0.85%/py). The linearized rates of adverse events in this study were found to be lower than earlier published results.

Conclusion

The results highlight the continued safety and performance of the TTK Chitra™ heart valve (TTKCHV) in the long term at 15 years.

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Title: Long-term evaluation of TTK Chitra™ heart valve prosthesis — a retrospective-prospective cohort study
Authors: Praveen Kerala Varma
Maniyal Vijayakumar
Gopichettipalayam Subbaratnam Bhuvaneshwar
Adarsh Syla Kumar
Neethu Krishna
Publication date: 03-12-2022
Publisher: Springer Nature Singapore
Keywords: Aortic Valve Replacement
Mitral Valve Replacement
Endocarditis
Aortic Valve Replacement
Mitral Valve Replacement
Aortic Valve Replacement
Mitral Valve Replacement
Published in: Indian Journal of Thoracic and Cardiovascular Surgery / Issue 1/2023
Print ISSN: 0970-9134
Electronic ISSN: 0973-7723
DOI: https://doi.org/10.1007/s12055-022-01437-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Long-term evaluation of TTK Chitra™ heart valve prosthesis — a retrospective-prospective cohort study

Abstract

Purpose

Methodology

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methodology

Results

Conclusion

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