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08-04-2024 | Original work

Mortality, Functional Status, and Quality of Life after 5 Years of Patients Admitted to Critical Care for Spontaneous Intracerebral Hemorrhage

Authors: Marina Gordillo-Resina, Consuelo Aranda-Martinez, Maria Dolores Arias-Verdú, Francisco Guerrero-López, Encarnación Castillo-Lorente, David Rodríguez-Rubio, Ricardo Rivera-López, Carmen Rosa-Garrido, Francisco Javier Gómez-Jiménez, Jesus Lafuente-Baraza, Eduardo Aguilar-Alonso, Miguel Angel Arráez-Sánchez, Ricardo Rivera-Fernández

Published in: Neurocritical Care

Abstract

Background

The objective of this study was to assess long-term outcome in patients with spontaneous intracerebral hemorrhage admitted to the intensive care unit.

Methods

Mortality and Glasgow Outcome Scale, Barthel Index, and 5-level EQ-5D version (EQ-5D-5L) scores were analyzed in a multicenter cohort study of three Spanish hospitals (336 patients). Mortality was also analyzed in the Medical Information Mart for Intensive Care III (MIMIC-III) database.

Results

The median (25th percentile-75th percentile) age was 62 (50–70) years, the median Glasgow Coma Score was 7 (4–11) points, and the median Acute Physiology and Chronic Health disease Classification System II (APACHE-II) score was 21 (15–26) points. Hospital mortality was 54.17%, mortality at 90 days was 56%, mortality at 1 year was 59.2%, and mortality at 5 years was 66.4%. In the Glasgow Outcome Scale, a normal or disabled self-sufficient situation was recorded in 21.5% of patients at 6 months, in 25.5% of patients after 1 year, and in 22.1% of patients after 5 years of follow-up (4.5% missing). The Barthel Index score of survivors improved over time: 50 (25–80) points at 6 months, 70 (35–95) points at 1 year, and 90 (40–100) points at 5 years (p < 0.001). Quality of life evaluated with the EQ-5D-5L at 1 year and 5 years indicated that greater than 50% of patients had no problems or slight problems in all items (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). In the MIMIC-III study (N = 1354), hospital mortality was 31.83% and was 40.5% at 90 days and 56.2% after 5 years.

Conclusions

In patients admitted to the intensive care unit with a diagnosis of nontraumatic intracerebral hemorrhage, hospital mortality up to 90 days after admission is very high. Between 90 days and 5 years after admission, mortality is not high. A large percentage of survivors presented a significant deficit in quality of life and functional status, although with progressive improvement over time. Five years after the hemorrhagic stroke, a survival of 30% was observed, with a good functional status seen in 20% of patients who had been admitted to the hospital.

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Title: Mortality, Functional Status, and Quality of Life after 5 Years of Patients Admitted to Critical Care for Spontaneous Intracerebral Hemorrhage
Authors: Marina Gordillo-Resina
Consuelo Aranda-Martinez
Maria Dolores Arias-Verdú
Francisco Guerrero-López
Encarnación Castillo-Lorente
David Rodríguez-Rubio
Ricardo Rivera-López
Carmen Rosa-Garrido
Francisco Javier Gómez-Jiménez
Jesus Lafuente-Baraza
Eduardo Aguilar-Alonso
Miguel Angel Arráez-Sánchez
Ricardo Rivera-Fernández
Publication date: 08-04-2024
Publisher: Springer US
Published in: Neurocritical Care
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-024-01960-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mortality, Functional Status, and Quality of Life after 5 Years of Patients Admitted to Critical Care for Spontaneous Intracerebral Hemorrhage

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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