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Neurocritical Care
Published in: Neurocritical Care 2/2018

Open Access 01-10-2018 | Original Article

Evaluation of a New Multiparameter Brain Probe for Simultaneous Measurement of Brain Tissue Oxygenation, Cerebral Blood Flow, Intracranial Pressure, and Brain Temperature in a Porcine Model

Authors: Marius M. Mader, Anna Leidorf, Andreas Hecker, Axel Heimann, Petra S. M. Mayr, Oliver Kempski, Beat Alessandri, Gabriele Wöbker

Published in: Neurocritical Care | Issue 2/2018

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Abstract

Background

A novel multiparameter brain sensor (MPBS) allows the simultaneous measurement of brain tissue oxygenation (ptiO2), cerebral blood flow (CBF), intracranial pressure (ICP), and brain temperature with a single catheter. This laboratory investigation evaluates the MPBS in an animal model in relation to established reference probes.

Methods

The study group consisted of 17 juvenile male pigs. Four MPBS and four reference probes were implanted per pig and compared simultaneously. The measured parameters were challenged by standardized provocations such as hyperoxia, dobutamine, and norepinephrine application, hypercapnia and hypoxia in combination with and without a controlled cortical impact (CCI) injury. Mean values over 2 min were collected for predefined time points and were analyzed using Bland–Altman plots.

Results

The protocol was successfully conducted in 15 pigs of which seven received CCI. ICP and ptiO2 were significantly influenced by the provocations. Subtraction of MPBS from reference values revealed a mean difference (limits of agreement) of 3.7 (− 20.5 to 27.9) mm Hg, − 2.9 (− 7.9 to 2.1) mm Hg, and 5.1 (− 134.7 to 145.0) % for ptiO2, ICP, and relative CBF, respectively.

Conclusions

The MPBS is a promising measurement tool for multiparameter neuromonitoring. The conducted study demonstrates the in vivo functionality of the probe. Comparison with standard probes revealed a deviation which is mostly analogous to other multiparameter devices. However, further evaluation of the device is necessary before it can reliably be used for clinical decision making.
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Metadata
Title
Evaluation of a New Multiparameter Brain Probe for Simultaneous Measurement of Brain Tissue Oxygenation, Cerebral Blood Flow, Intracranial Pressure, and Brain Temperature in a Porcine Model
Authors
Marius M. Mader
Anna Leidorf
Andreas Hecker
Axel Heimann
Petra S. M. Mayr
Oliver Kempski
Beat Alessandri
Gabriele Wöbker
Publication date
01-10-2018
Publisher
Springer US
Published in
Neurocritical Care / Issue 2/2018
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-018-0541-9

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