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Neurocritical Care
Published in: Neurocritical Care 2/2016

01-10-2016 | Original Article

Risk Factors for Infections Related to Lumbar Drainage in Spontaneous Subarachnoid Hemorrhage

Authors: Hongsheng Liang, Liyang Zhang, Aili Gao, Yonghua Li, Zhenfeng Jiang, Fulan Hu, Bin Shao, Yan Liu, Xiangtong Zhang

Published in: Neurocritical Care | Issue 2/2016

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Abstract

Background

A solid knowledge associated with lumbar drainage (LD)-related infections in spontaneous subarachnoid hemorrhage (SAH) patients is necessary and that would be useful in taking effective measures to cope with this complication. We aimed to describe incidence rates and risk factors associated with LD-related infections in SAH patients.

Methods

A retrospective review was performed on SAH patients who underwent LD between July 2010 and August 2015. Patient charts were reviewed to retrieve demographic, clinical, and laboratory data. LD-related infections were defined based on culture results of cerebrospinal fluid in combination with clinical symptoms. Infection rates were calculated, and a logistic regression model was developed to identify risk factors.

Results

A total of 629 SAH patients (25–82 years age range, 42.8 % male) were treated with LD in the period. LD-related infections were identified in 36 patients (5.7 %). Longer duration of LD (≥4 days: p = 0.0037) and puncture site leakage (p < 0.0001) appeared to be risk factors for infection. The infection rate increased with length of the hospital stay (16–20 days: p = 0.0032; ≥21 days: p = 0.0007). 84.6 % of the isolated bacteria were Gram-positive, and the most commonly associated pathogens were Methicillin-resistant coagulase-negative Staphylococcus (MRCNS, 61.5 %).

Conclusions

The patients with LD for more than 4 days or with puncture site leakage had more risk of infection. Infected patients were more likely to stay longer in the hospital. MRCNS were identified as the most frequent causal pathogens. And the use of antibiotics during LD did not appear to reduce the risk of infection.
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Metadata
Title
Risk Factors for Infections Related to Lumbar Drainage in Spontaneous Subarachnoid Hemorrhage
Authors
Hongsheng Liang
Liyang Zhang
Aili Gao
Yonghua Li
Zhenfeng Jiang
Fulan Hu
Bin Shao
Yan Liu
Xiangtong Zhang
Publication date
01-10-2016
Publisher
Springer US
Published in
Neurocritical Care / Issue 2/2016
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-015-0239-1

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