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Published in:

01-02-2013

Intracranial Pressure Dose and Outcome in Traumatic Brain Injury

Authors: Kevin N. Sheth, Deborah M. Stein, Bizhan Aarabi, Peter Hu, Joseph A. Kufera, Thomas M. Scalea, Daniel F. Hanley

Published in: Neurocritical Care | Issue 1/2013

Abstract

Objective

Detecting and treating elevated intracranial pressure (ICP) is a cornerstone of management in patients with severe traumatic brain injury. The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome.

Methods

Single center observational study using prospectively collected data at a University hospital, level one-trauma center. Sixty prospective patients with severe traumatic brain injury were prospectively enrolled over a 2-year period. Intracranial pressure measurements were captured using a real-time automated, high resolution vital signs data recording system. Mortality and functional outcome were assessed at 30 days, 3 and 6 months using Extended Glasgow Outcome Scale.

Results

Increasing elevated intracranial pressure time dose was associated with mortality (OR 1.08; 95 % confidence interval [CI], 1.01–1.15, p = 0.03) and poor functional outcome at 3 (OR 1.04; CI 1.00–1.07, p = 0.03) and 6 months (1.04; CI 1.01–1.08, p = 0.02). However, there was no association between episodic ICP data and outcome.

Conclusions

These results suggest that pressure time dose measurement of intracranial pressure may be used to predict outcome in severe traumatic brain injury and may be a candidate biomarker in this disease.

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Title: Intracranial Pressure Dose and Outcome in Traumatic Brain Injury
Authors: Kevin N. Sheth
Deborah M. Stein
Bizhan Aarabi
Peter Hu
Joseph A. Kufera
Thomas M. Scalea
Daniel F. Hanley
Publication date: 01-02-2013
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 1/2013
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-012-9780-3

At a glance: The STEP trials

Springer Medicine

Intracranial Pressure Dose and Outcome in Traumatic Brain Injury

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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