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01-04-2010 | Original Article

Comparison of the Predictability of Neurological Outcome by Serum Procalcitonin and Glial Fibrillary Acidic Protein in Postcardiac-Arrest Patients

Authors: Hiromi Hayashida, Tadashi Kaneko, Shunji Kasaoka, Chiyomi Oshima, Takashi Miyauchi, Motoki Fujita, Yasutaka Oda, Ryosuke Tsuruta, Tsuyoshi Maekawa

Published in: Neurocritical Care | Issue 2/2010

Abstract

Background

In past research, procalcitonin (PCT) and glial fibrillary acidic protein (GFAP) have been reported to be useful biomarkers in predicting neurological outcome after the return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrest (CA), although they have only been studied separately. In this study, we compared the usefulness of PCT and GFAP in predicting neurological outcome.

Methods

This study was a retrospective, single-center analysis, conducted in the intensive-care unit of a university hospital. Twenty-one sequential post-CA patients were included. Serum samples were collected from patients at 12 and 24 h after ROSC. Serum PCT and GFAP were measured and compared in patients with favorable and unfavorable neurological outcomes, evaluated at 6 months using the Glasgow–Pittsburgh Cerebral Performance Categories.

Results

Serum PCT was significantly higher at 12 and 24 h in patients with unfavorable outcomes (P = 0.004 and 0.002, respectively). Serum GFAP was not significantly higher at 12 and 24 h in patients with unfavorable outcomes (P = 0.118 and 0.079, respectively). The combination of PCT and GFAP showed high predictive value for unfavorable outcomes (86.7% sensitivity and 100% specificity at 12 h; 100% sensitivity and 83.3% specificity at 24 h).

Conclusion

Serum PCT is a marker of unfavorable neurological outcome in post-CA patients, and is superior to serum GFAP in the early phase.

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Title: Comparison of the Predictability of Neurological Outcome by Serum Procalcitonin and Glial Fibrillary Acidic Protein in Postcardiac-Arrest Patients
Authors: Hiromi Hayashida
Tadashi Kaneko
Shunji Kasaoka
Chiyomi Oshima
Takashi Miyauchi
Motoki Fujita
Yasutaka Oda
Ryosuke Tsuruta
Tsuyoshi Maekawa
Publication date: 01-04-2010
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 2/2010
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-009-9318-5

At a glance: The STEP trials

Springer Medicine

Comparison of the Predictability of Neurological Outcome by Serum Procalcitonin and Glial Fibrillary Acidic Protein in Postcardiac-Arrest Patients

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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