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01-02-2017 | Therapeutic Aspects in Autoimmunity

The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature

Authors: M. Infantino, F. Meacci, V. Grossi, M. Manfredi, F. Li Gobbi, P. Sarzi-Puttini, F. Atzeni, M. Benucci

Published in: Immunologic Research | Issue 1/2017

Abstract

Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.

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Title: The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature
Authors: M. Infantino
F. Meacci
V. Grossi
M. Manfredi
F. Li Gobbi
P. Sarzi-Puttini
F. Atzeni
M. Benucci
Publication date: 01-02-2017
Publisher: Springer US
Published in: Immunologic Research / Issue 1/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-016-8836-4

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The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature

Abstract

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Abstract

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