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Immunologic Research
Published in: Immunologic Research 2/2015

01-06-2015 | Interpretive synthesis review article

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

Authors: Mamoona Noreen, Muhammad Arshad

Published in: Immunologic Research | Issue 2/2015

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Abstract

Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control. Polymorphisms in genes associated with inflammatory pathway especially influence the outcome of diseases. TLR2 makes heterodimer with TLR1 or TLR6 and recognizes a wide variety of microbial ligands. In this review, we summarize studies of polymorphisms in genes encoding TLR1, TLR2, TLR4, TLR6, and most polymorphic adaptor protein, Mal/TIRAP, revealing their effect on susceptibility to diseases.
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Metadata
Title
Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility
Authors
Mamoona Noreen
Muhammad Arshad
Publication date
01-06-2015
Publisher
Springer US
Published in
Immunologic Research / Issue 2/2015
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-015-8640-6

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