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Immunologic Research
Published in: Immunologic Research 1-3/2012

01-09-2012 | Singapore Immunology Network

The three human monocyte subsets: implications for health and disease

Authors: Kok Loon Wong, Wei Hseun Yeap, June Jing Yi Tai, Siew Min Ong, Truong Minh Dang, Siew Cheng Wong

Published in: Immunologic Research | Issue 1-3/2012

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Abstract

Human blood monocytes are heterogeneous and conventionally subdivided into two subsets based on CD16 expression. Recently, the official nomenclature subdivides monocytes into three subsets, the additional subset arising from the segregation of the CD16+ monocytes into two based on relative expression of CD14. Recent whole genome analysis reveal that specialized functions and phenotypes can be attributed to these newly defined monocyte subsets. In this review, we discuss these recent results, and also the description and utility of this new segregation in several disease conditions. We also discuss alternative markers for segregating the monocyte subsets, for example using Tie-2 and slan, which do not necessarily follow the official method of segregating monocyte subsets based on relative CD14 and CD16 expressions.
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Metadata
Title
The three human monocyte subsets: implications for health and disease
Authors
Kok Loon Wong
Wei Hseun Yeap
June Jing Yi Tai
Siew Min Ong
Truong Minh Dang
Siew Cheng Wong
Publication date
01-09-2012
Publisher
Springer-Verlag
Published in
Immunologic Research / Issue 1-3/2012
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-012-8297-3

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