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Immunologic Research
Published in: Immunologic Research 2-3/2011

01-08-2011 | UNIVERSITY OF PITTSBURGH IMMUNOLOGY 2011

Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease

Authors: Karen A. Norris, Alison Morris

Published in: Immunologic Research | Issue 2-3/2011

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Abstract

With increases in the immunocompromised patient population and aging of the HIV+ population, the risk of serious fungal infections and their complications will continue to rise. In these populations, infection with the fungal opportunistic pathogen Pneumocystis jirovecii remains a leading cause of morbidity and mortality. Infection with Pneumocystis (Pc) has been shown to be associated with the development of chronic obstructive pulmonary disease (COPD) in human subjects with and without HIV infection and in non-human primate models of HIV infection. In human studies and in a primate model of HIV/Pc co-infection, we have shown that antibody response to the Pc protein, kexin (KEX1), correlates with protection from colonization, Pc pneumonia, and COPD. These findings support the hypothesis that immunity to KEX1 may be critical to controlling Pc colonization and preventing or slowing development of COPD.
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Metadata
Title
Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease
Authors
Karen A. Norris
Alison Morris
Publication date
01-08-2011
Publisher
Humana Press Inc
Published in
Immunologic Research / Issue 2-3/2011
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-011-8218-x

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