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Immunologic Research
Published in: Immunologic Research 2-3/2011

01-08-2011 | UNIVERSITY OF PITTSBURGH IMMUNOLOGY 2011

Regulation of NF-κB induction by TCR/CD28

Authors: Jing Cheng, Angela Montecalvo, Lawrence P. Kane

Published in: Immunologic Research | Issue 2-3/2011

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Abstract

NF-κB family transcription factors are a common downstream target for inducible transcription mediated by many different cell-surface receptors, especially those receptors involved in inflammation and adaptive immunity. It is now clear that different classes of receptors employ different proximal signaling strategies to activate the common NF-κB signaling components, such as the IKK complex. For antigen receptors expressed by T and B cells, this pathway requires a complex of proteins including the proteins Carma1, Bcl10, and Malt1. Here, we discuss some of what is known about regulation of these proteins downstream of TCR/CD3 and co-stimulatory CD28 signaling. We also discuss another unique aspect of TCR-mediated NF-κB activation, i.e., the spatial restriction imposed on signaling events by the formation of the immunological synapse between a T cell and antigen-presenting cell presenting specific peptide/MHC.
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Metadata
Title
Regulation of NF-κB induction by TCR/CD28
Authors
Jing Cheng
Angela Montecalvo
Lawrence P. Kane
Publication date
01-08-2011
Publisher
Humana Press Inc
Published in
Immunologic Research / Issue 2-3/2011
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-011-8216-z

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