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Published in:

01-12-2009

T helper cytokine patterns: defined subsets, random expression, and external modulation

Authors: Tim R. Mosmann, James J. Kobie, F. Eun-Hyung Lee, Sally A. Quataert

Published in: Immunologic Research | Issue 2-3/2009

Abstract

Although T cell effector subsets, defined by cytokine patterns, have been recognized for more than 20 years, the functional cytokine expression patterns in vivo are still in considerable doubt, particularly for human T cells. At least three new subsets have been recently identified, but the committed cytokine pattern of a T cell (e.g., Th1 cells produce IL-2, interferon-gamma, and lymphotoxin) may differ from the expression pattern of one cell on one occasion, which may be a subset of its full potential. Recent advances in flow cytometry allowed detailed cytokine patterns of antigen-stimulated cells to be identified directly ex vivo. These patterns are clearly more diverse than the major subsets identified as committed phenotypes. Additional contributions to diversity may include new committed subsets, random expression of only part of the committed pattern, and modification of the expression patterns by cytokines and other mediators.

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Title: T helper cytokine patterns: defined subsets, random expression, and external modulation
Authors: Tim R. Mosmann
James J. Kobie
F. Eun-Hyung Lee
Sally A. Quataert
Publication date: 01-12-2009
Publisher: Humana Press Inc
Published in: Immunologic Research / Issue 2-3/2009
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-009-8098-5

ACC 2024 Congress

Springer Medicine

T helper cytokine patterns: defined subsets, random expression, and external modulation

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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