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Immunologic Research
Published in: Immunologic Research 1-3/2009

01-03-2009

Neutrophil apoptosis and the resolution of infection

Authors: Adam D. Kennedy, Frank R. DeLeo

Published in: Immunologic Research | Issue 1-3/2009

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Abstract

Polymorphonuclear leukocytes (PMNs) are the most abundant white cell in humans and an essential component of the innate immune system. PMNs are typically the first type of leukocyte recruited to sites of infection or areas of inflammation. Ingestion of microorganisms triggers production of reactive oxygen species and fusion of cytoplasmic granules with forming phagosomes, leading to effective killing of ingested microbes. Phagocytosis of bacteria typically accelerates neutrophil apoptosis, which ultimately promotes the resolution of infection. However, some bacterial pathogens alter PMN apoptosis to survive and thereby cause disease. Herein, we review PMN apoptosis and the ability of microorganisms to alter this important process.
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Metadata
Title
Neutrophil apoptosis and the resolution of infection
Authors
Adam D. Kennedy
Frank R. DeLeo
Publication date
01-03-2009
Publisher
Humana Press Inc
Published in
Immunologic Research / Issue 1-3/2009
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-008-8049-6

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