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Forensic Science, Medicine and Pathology
Published in: Forensic Science, Medicine and Pathology 3/2020

01-09-2020 | Vasculitis | Case Report

Sudden death of a young adult with coronary artery vasculitis, coronary aneurysms, parvovirus B19 infection and Kawasaki disease

Authors: Stefan Flossdorf, Karl Heinz Schiwy-Bochat, Daniela Teifel, Jochen W. U. Fries, Markus A. Rothschild

Published in: Forensic Science, Medicine and Pathology | Issue 3/2020

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Abstract

We present a case of a 20-year-old man who suffered from Kawasaki disease (KD) associated with a florid parvovirus infection, and who died suddenly from thrombotic occlusion of the coronary arteries. The autopsy revealed several aneurysms of the coronary arteries, a chronic vasculitis and a myofibroblast proliferation leading to focal luminal narrowing. The inflammatory response as well as the detection of the viral particles by PCR in blood and in the lesional tissue demonstrated a possible cause by Parvovirus infection. The expression of endoglin on endothelial cells of neoangiogenesis indicates the involvement of the TGF-beta pathway, necessary for maintaining chronic inflammation. In addition, a possible connection between the intake of methylphenidate, arteritis and a possible pre-existing heart disease must be discussed. Furthermore, KD must also be considered as a cause of sudden death in the adult population.
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Metadata
Title
Sudden death of a young adult with coronary artery vasculitis, coronary aneurysms, parvovirus B19 infection and Kawasaki disease
Authors
Stefan Flossdorf
Karl Heinz Schiwy-Bochat
Daniela Teifel
Jochen W. U. Fries
Markus A. Rothschild
Publication date
01-09-2020
Publisher
Springer US
Published in
Forensic Science, Medicine and Pathology / Issue 3/2020
Print ISSN: 1547-769X
Electronic ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-020-00263-y

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