Skip to main content
Top
Published in: Forensic Science, Medicine and Pathology 2/2019

01-06-2019 | Lessons from the Museum

Classical syphilitic lesions from the museum

Author: Roger W. Byard

Published in: Forensic Science, Medicine and Pathology | Issue 2/2019

Login to get access

Abstract

Syphilis is an increasingly diagnosed venereal disease which has four distinctive stages that may last over decades if appropriate treatment is not given. Review of the files of the Pathology Museum in the Faculty of Medicine at The University of Adelaide revealed three cases with classical cardiovascular and neurological findings. Case 1: An 80-year-old man with a large syphilitic aneurysm of the ascending aorta with a smaller aneurysm of the proximal descending aorta. Case 2: A 56-year-old man with chronic syphilitic meningoencephalitis with cerebral atrophy. Case 3: A 77-year-old man with tabes dorsalis. Given the increase in cases coming to medical attention in recent years due to high-risk sexual activity, migration, travel and reduced access to medical treatment, an awareness of the classical features of syphilis is appropriate as some cases will undoubtedly require medicolegal evaluation.
Literature
4.
go back to reference Hook EW. Syphilis. In: Goldman L, Schafer AI, editors. Goldman’s Cecil medicine. 24th ed. Toronto: Elsevier; 2011. p. 1922–9. Hook EW. Syphilis. In: Goldman L, Schafer AI, editors. Goldman’s Cecil medicine. 24th ed. Toronto: Elsevier; 2011. p. 1922–9.
5.
go back to reference Byard RW. Syphilis – cardiovascular manifestations of the great imitator. J Forensic Sci. 2018;64:1312–5.CrossRef Byard RW. Syphilis – cardiovascular manifestations of the great imitator. J Forensic Sci. 2018;64:1312–5.CrossRef
9.
go back to reference La Fond RE, Lukehart SA. Biological basis for syphilis. Clin Microbiol Rev. 2006;19:29–49.CrossRef La Fond RE, Lukehart SA. Biological basis for syphilis. Clin Microbiol Rev. 2006;19:29–49.CrossRef
10.
go back to reference Tsokos M. Syphilitic aortic aneurysm rupture as cause of sudden death. Forensic Sci Med Pathol. 2012;8:325–6.CrossRefPubMed Tsokos M. Syphilitic aortic aneurysm rupture as cause of sudden death. Forensic Sci Med Pathol. 2012;8:325–6.CrossRefPubMed
11.
go back to reference Roberts WC, Barbin CM, Weissenborn MR, Ko JM, Henry AC. Syphilis as a cause of thoracic aortic aneurysm. Am J Cardiol. 2015;116:1298–303.CrossRefPubMed Roberts WC, Barbin CM, Weissenborn MR, Ko JM, Henry AC. Syphilis as a cause of thoracic aortic aneurysm. Am J Cardiol. 2015;116:1298–303.CrossRefPubMed
12.
go back to reference Roberts WC, Ko JM, Vowels TJ. Natural history of syphilitic aortitis. Am J Cardiol. 2009;104:1578–87.CrossRefPubMed Roberts WC, Ko JM, Vowels TJ. Natural history of syphilitic aortitis. Am J Cardiol. 2009;104:1578–87.CrossRefPubMed
14.
15.
go back to reference Stern R. A study of the histopathology of tabes dorsalis with special reference to Richter’s theory of its pathogenesis. Brain. 1929;52:295–316.CrossRef Stern R. A study of the histopathology of tabes dorsalis with special reference to Richter’s theory of its pathogenesis. Brain. 1929;52:295–316.CrossRef
16.
go back to reference Brown E, Gray F. Bacterial infections. In: Love S, Louis D, Ellison DW, editors. Greenfield’s Neuropathology. 8th ed. Boca Raton: CRC Press; 2008. p. 1431. Brown E, Gray F. Bacterial infections. In: Love S, Louis D, Ellison DW, editors. Greenfield’s Neuropathology. 8th ed. Boca Raton: CRC Press; 2008. p. 1431.
17.
go back to reference Park KH, Lee MS, Hong IK, et al. Bone involvement in secondary syphilis: a case report and systematic review of the literature. Sex Transm Dis. 2014;41:532–7.CrossRefPubMed Park KH, Lee MS, Hong IK, et al. Bone involvement in secondary syphilis: a case report and systematic review of the literature. Sex Transm Dis. 2014;41:532–7.CrossRefPubMed
19.
go back to reference Son C, Samples D, Brenner A, Floyd J. Osteolytic calvarial lesions as initial presentation of latent neurosyphilis. J Clin Neurosci. 2010;22:909–10.CrossRef Son C, Samples D, Brenner A, Floyd J. Osteolytic calvarial lesions as initial presentation of latent neurosyphilis. J Clin Neurosci. 2010;22:909–10.CrossRef
20.
go back to reference Newman L, Kamb M, Hawkes S, Gomez G, Say L, Seuc A, et al. Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data. PLoS Med. 2013;10:e1001396.CrossRefPubMedPubMedCentral Newman L, Kamb M, Hawkes S, Gomez G, Say L, Seuc A, et al. Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data. PLoS Med. 2013;10:e1001396.CrossRefPubMedPubMedCentral
21.
go back to reference Nyatsanza F, Tipple C. Syphilis: presentations in general medicine. Clin Med. 2016;16:184–8.CrossRef Nyatsanza F, Tipple C. Syphilis: presentations in general medicine. Clin Med. 2016;16:184–8.CrossRef
22.
go back to reference Forrest CE, Ward A. Clinical diagnosis of syphilis: a ten-year retrospective analysis in a south Australian urban sexual health clinic. Int J STD AIDS. 2016;27:1334–7.CrossRefPubMed Forrest CE, Ward A. Clinical diagnosis of syphilis: a ten-year retrospective analysis in a south Australian urban sexual health clinic. Int J STD AIDS. 2016;27:1334–7.CrossRefPubMed
Metadata
Title
Classical syphilitic lesions from the museum
Author
Roger W. Byard
Publication date
01-06-2019
Publisher
Springer US
Published in
Forensic Science, Medicine and Pathology / Issue 2/2019
Print ISSN: 1547-769X
Electronic ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-018-0012-9

Other articles of this Issue 2/2019

Forensic Science, Medicine and Pathology 2/2019 Go to the issue