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Forensic Science, Medicine and Pathology
Published in: Forensic Science, Medicine and Pathology 1/2018

Open Access 01-03-2018 | Original Article

Bystin (BYSL) as a possible marker of severe hypoxic-ischemic changes in neuropathological examination of forensic cases

Authors: Mieszko Olczak, Dominik Chutorański, Magdalena Kwiatkowska, Dorota Samojłowicz, Sylwia Tarka, Teresa Wierzba-Bobrowicz

Published in: Forensic Science, Medicine and Pathology | Issue 1/2018

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Abstract

Bystin (BYSL) is a 306-amino acid protein encoded in humans by the BYSL gene located on the 6p21.1 chromosome. It is conserved across a wide range of eukaryotes. BYSL was reported to be a sensitive marker for the reactive astrocytes induced by ischemia/reperfusion and chemical hypoxia in vitro and is considered to be one of the common characteristics of astrogliosis. In our study we examined whether BYSL could be used as a marker for hypoxic-ischemic changes in forensic cases. Groups suspected of acute hypoxic-ischemic changes presented strong BYSL expression in the cytoplasm of neocortical neurons especially in layers 3–5, that seemed to be short-lasting. In the hypoxic-ischemic-reperfusion group we did not find BYSL expression. BYSL expression in the cytoplasm of cortical neurons was minimal in the control group (cardiac arrest). BYSL seems to be a promising early marker of severe hypoxic-ischemic changes in neuropathological examination of forensic cases and certainly requires further studies.
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Metadata
Title
Bystin (BYSL) as a possible marker of severe hypoxic-ischemic changes in neuropathological examination of forensic cases
Authors
Mieszko Olczak
Dominik Chutorański
Magdalena Kwiatkowska
Dorota Samojłowicz
Sylwia Tarka
Teresa Wierzba-Bobrowicz
Publication date
01-03-2018
Publisher
Springer US
Published in
Forensic Science, Medicine and Pathology / Issue 1/2018
Print ISSN: 1547-769X
Electronic ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-017-9942-x

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