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Open Access 01-06-2021 | Stroke | Mini-reviews

The Gut Ecosystem: A Critical Player in Stroke

Authors: Rosa Delgado Jiménez, Corinne Benakis

Published in: NeuroMolecular Medicine | Issue 2/2021

Abstract

The intestinal microbiome is emerging as a critical factor in health and disease. The microbes, although spatially restricted to the gut, are communicating and modulating the function of distant organs such as the brain. Stroke and other neurological disorders are associated with a disrupted microbiota. In turn, stroke-induced dysbiosis has a major impact on the disease outcome by modulating the immune response. In this review, we present current knowledge on the role of the gut microbiome in stroke, one of the most devastating brain disorders worldwide with very limited therapeutic options, and we discuss novel insights into the gut-immune-brain axis after an ischemic insult. Understanding the nature of the gut bacteria-brain crosstalk may lead to microbiome-based therapeutic approaches that can improve patient recovery.

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Title: The Gut Ecosystem: A Critical Player in Stroke
Authors: Rosa Delgado Jiménez
Corinne Benakis
Publication date: 01-06-2021
Publisher: Springer US
Keywords: Stroke
Respiratory Microbiota
Published in: NeuroMolecular Medicine / Issue 2/2021
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-020-08633-z

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