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01-09-2017 | Review Paper

Models for Studying Myelination, Demyelination and Remyelination

Authors: I. Osorio-Querejeta, M. Sáenz-Cuesta, M. Muñoz-Culla, D. Otaegui

Published in: NeuroMolecular Medicine | Issue 2-3/2017

Abstract

One of the most widely studied demyelinating diseases is multiple sclerosis, which is characterised by the appearance of demyelinating plaques, followed by myelin regeneration. Nevertheless, with disease progression, remyelination tends to fail, increasing the characteristic neurodegeneration of the disease. It is essential to understand the mechanisms that operate in the processes of myelination, demyelination and remyelination to develop treatments that promote the production of new myelin, thereby protecting the central nervous system. A huge variety of models have been developed to help improve our understanding of these processes. Nevertheless, no single model allows us to study all the processes involved in remyelination and usually more than one is needed to provide a full picture of related mechanisms. In this review, we summarise the most commonly used models for studying myelination, demyelination and remyelination and we analyse them critically to outline the most suitable ways of using them.

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Title: Models for Studying Myelination, Demyelination and Remyelination
Authors: I. Osorio-Querejeta
M. Sáenz-Cuesta
M. Muñoz-Culla
D. Otaegui
Publication date: 01-09-2017
Publisher: Springer US
Published in: NeuroMolecular Medicine / Issue 2-3/2017
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-017-8442-1

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Models for Studying Myelination, Demyelination and Remyelination

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