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01-12-2016 | Review Paper

Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases

Authors: Hwa Jeong You, Jae Hyon Park, Helios Pareja-Galeano, Alejandro Lucia, Jae Il Shin

Published in: NeuroMolecular Medicine | Issue 4/2016

Abstract

Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges.

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Title: Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases
Authors: Hwa Jeong You
Jae Hyon Park
Helios Pareja-Galeano
Alejandro Lucia
Jae Il Shin
Publication date: 01-12-2016
Publisher: Springer US
Published in: NeuroMolecular Medicine / Issue 4/2016
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-016-8407-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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