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01-12-2012 | Original Paper

Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory

Authors: Robert Nisticò, Virve Cavallucci, Sonia Piccinin, Simone Macrì, Marco Pignatelli, Bisan Mehdawy, Fabio Blandini, Giovanni Laviola, Davide Lauro, Nicola B. Mercuri, Marcello D’Amelio

Published in: NeuroMolecular Medicine | Issue 4/2012

Abstract

The insulin receptor (IR) is a protein tyrosine kinase playing a pivotal role in the regulation of peripheral glucose metabolism and energy homoeostasis. IRs are also abundantly distributed in the cerebral cortex and hippocampus, where they regulate synaptic activity required for learning and memory. As the major anabolic hormone in mammals, insulin stimulates protein synthesis partially through the activation of the PI3K/Akt/mTOR pathway, playing fundamental roles in neuronal development, synaptic plasticity and memory. Here, by means of a multidisciplinary approach, we report that long-term synaptic plasticity and recognition memory are impaired in IR β-subunit heterozygous mice. Since IR expression is diminished in type-2 diabetes as well as in Alzheimer’s disease (AD) patients, these data may provide a mechanistic link between insulin resistance, impaired synaptic transmission and cognitive decline in humans with metabolic disorders.

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Title: Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory
Authors: Robert Nisticò
Virve Cavallucci
Sonia Piccinin
Simone Macrì
Marco Pignatelli
Bisan Mehdawy
Fabio Blandini
Giovanni Laviola
Davide Lauro
Nicola B. Mercuri
Marcello D’Amelio
Publication date: 01-12-2012
Publisher: Humana Press Inc
Published in: NeuroMolecular Medicine / Issue 4/2012
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-012-8184-z

At a glance: The STEP trials

Springer Medicine

Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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