Top

Published in:

Open Access 01-12-2011 | Original Paper

Renalase Gene Polymorphisms in Patients With Type 2 Diabetes, Hypertension and Stroke

Authors: Monika Buraczynska, Pawel Zukowski, Kinga Buraczynska, Slawomir Mozul, Andrzej Ksiazek

Published in: NeuroMolecular Medicine | Issue 4/2011

Abstract

Renalase is a novel, recently identified, flavin adenine dinucleotide-dependent amine oxidase. It is secreted by the kidney and metabolizes circulating catecholamines. Renalase has significant hemodynamic effects, therefore it is likely to participate in the regulation of cardiovascular function.The aim of our study was to investigate the involvement of renalase gene polymorphisms in hypertension in type 2 diabetes patients. A total of 892 patients and 400 controls were genotyped with three SNPs in the renalase gene. The C allele of rs2296545 SNP was associated with hypertension (P < 0.01). For rs2576178 SNP, frequencies in hypertensive patients differed from controls, but not from normotensive patients. For rs10887800 SNP, the differences in the G allele frequencies were observed in hypertensive patients with stroke, with 66% of patients being GG homozygotes. To confirm observed association we later genotyped 130 stroke patients without diabetes. The OR for risk allele was 1.79 (95% CI 1.33–2.41). In conclusion, the renalase gene polymorphism was associated with hypertension in type 2 diabetes patients. The most interesting result is a strong association of the rs10887800 polymorphism with stroke in patients with and without diabetes. The G allele of this polymorphism might thus be useful in identifying diabetes patients at increased risk of stroke.

Adeyemo, A., Gerry, N., Chen, G., Herbert, A., Doumatey, A., Huang, H., et al. (2009). A genome-wide association study of hypertension and blood pressure in African Americans. Public Library of Science Genetics, 5, e1000564.PubMed

Aronow, W. S. (2008). Hypertension and the older diabetic. Clinics in Geriatric Medicine, 24, 489–501.PubMedCrossRef

Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., et al. (2009). Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics, 41, 703–707.PubMedCrossRef

Cowley, A. W., Jr. (2006). The genetic dissection of essential hypertension. Nature Reviews Genetics, 7, 829–840.PubMedCrossRef

Derosa, G., Salvadeo, S., & Cicero, A. F. (2006). Recommendations for the treatment of hypertension in patients with DM: Critical evaluation based on clinical trials. Current Clinical Pharmacology, 1, 21–33.PubMedCrossRef

Desir, G. V. (2007). Renalase is a novel renal hormone that regulates cardiovascular function. Journal of the American Society of Hypertension, 1, 99–103.PubMedCrossRef

Desir, G. V. (2008). Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion in Nephrology and Hypertension, 17, 181–185.PubMedCrossRef

Desir, G. V. (2011). Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion in Nephrology and Hypertension, 20, 31–36.PubMedCrossRef

Gu, R., Lu, W., Xie, J., Bai, J., & Xu, B. (2011). Renalase deficiency in heart failure model of rats–a potential mechanism underlying circulating norepinephrine accumulation. Public Library of Science, 6, e14633.

Kannel, V. B. (2000). Elevated systolic blood pressure as a cardiovascular risk factor. American Journal of Cardiology, 85, 251–255.PubMedCrossRef

Li, G., Xu, J., Wang, P., Velazquez, H., Li, Y., Wu, Y., et al. (2008). Catecholamines regulate the activity, secretion, and synthesis of renalase. Circulation, 117, 1277–1282.PubMedCrossRef

Madisen, L., Hoar, D. I., Holroyd, C. D., Crisp, M., & Hodes, M. E. (1987). The banking : The effects of storage of blood and isolated DNA on the integrity of DNA. American Journal of Medical Genetics, 27, 379–390.PubMedCrossRef

Matarin, M., Singleton, A., Hardy, J., & Meschia, J. (2010). The genetics of ischaemic stroke. Journal of Internal Medicine, 267, 139–155.PubMedCrossRef

Mazzone, T. (2007). Prevention of macrovascular disease in patients with diabetes mellitus: Opportunities for intervention. American Journal of Medicine, 120, S26–S32.PubMedCrossRef

Puddu, P., Puddu, G. M., Cravero, E., Ferrari, E., & Muscari, A. (2007). The genetic basis of essential hypertension. Acta Cardiologica, 62, 281–293.PubMedCrossRef

Rampersaud, E., Damcott, C. M., Fu, M., Shen, H., McArdle, P., et al. (2007). Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the old order Amish. Diabetes, 56, 3053–3062.PubMedCrossRef

Reddy, M. V., Wang, H., Liu, S., Bode, B., Reed, J. C., et al. (2011). Association between type 1 diabetes and GWAS SNPs in the southwest US Caucasian population. Genes & Immunity, 12, 208–212.CrossRef

Rohr, J., Kittner, S., Feeser, B., Hebel, J. R., Whyte, M. G., Weinstein, A., et al. (1996). Traditional risk factors and ischemic stroke in young adults: The Baltimore-Washington Cooperative Young Stroke Study. Archives of Neurology, 53, 603–607.PubMed

Sharma, V., & McNeill, J. H. (2006). The etiology of hypertension in the metabolic syndrome part two: The gene environment interaction. Current Vascular Pharmacology, 4, 305–320.PubMedCrossRef

Sowers, J. R. (2004). Insulin resistance and hypertension. American Journal of Physiology. Heart and Circulatory Physiology., 286, H1597–H1602.PubMedCrossRef

Sowers, J. R., Epstein, M., & Frohlich, E. D. (2001). Diabetes, hypertension and cardiovascular disease. An update. Hypertension, 37, 1053–1059.PubMed

Wong, W. T., Wong, S. L., Tian, X. Y., & Huang, Y. (2010). Endothelial dysfunction: The common consequence in diabetes and hypertension. Cardiovascular Pharmacology, 55, 300–307.CrossRef

World Health Organization. International Society of Hypertension Guideline for Management of Hypertension. (1999). Journal of Hypertension, 17, 151–183.

Wu, Y., Xu, J., Velazquez, H., Wang, P., Li, G., Liu, D., et al. (2011). Renalase deficiency aggravates ischemic myocardial damage. Kidney International, 79, 853–860.PubMedCrossRef

Xu, J., Li, G., Wang, P., Velazquez, H., Yao, X., Li, Y., et al. (2005). Renalase is a novel soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal of Clinical Investigation, 115, 1275–1280.PubMed

Zhao, Q., Fan, Z., He, J., Chen, S., Li, H., Zhang, P., et al. (2007). Renalase gene is a novel susceptibility gene for essential hypertension: A two-stage association study in northern Han Chinese population. Journal of Molecular Medicine, 85, 877–885.PubMedCrossRef

Title: Renalase Gene Polymorphisms in Patients With Type 2 Diabetes, Hypertension and Stroke
Authors: Monika Buraczynska
Pawel Zukowski
Kinga Buraczynska
Slawomir Mozul
Andrzej Ksiazek
Publication date: 01-12-2011
Publisher: Humana Press Inc
Published in: NeuroMolecular Medicine / Issue 4/2011
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-011-8158-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Renalase Gene Polymorphisms in Patients With Type 2 Diabetes, Hypertension and Stroke

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2011

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

Proteomic CNS Profile of Delayed Cognitive Impairment in Mice Exposed to Gulf War Agents

Association Study of Brain-Derived Neurotrophic Factor Gene Polymorphisms and Body Weight Change in Schizophrenic Patients Under Long-Term Atypical Antipsychotic Treatment

Chronic Dichlorvos Exposure: Microglial Activation, Proinflammatory Cytokines and Damage to Nigrostriatal Dopaminergic System

(−)-Epigallocatechin-3-gallate Protects Against Neuronal Cell Death and Improves Cerebral Function After Traumatic Brain Injury in Rats

Neuroprotective and Anti-Oxidative Effects of the Hemodialysate Actovegin on Primary Rat Neurons in Vitro