Musculoskeletal oncology encompasses a widening array of investigation, and an ever-expanding spectrum of disciplines are involved in our research. Molecular genetics, developmental biology, epidemiology, prognostication, environmental pathogens, imaging advances, surgical strategies, pathological (re)classification, reconstruction methods, implant fixation, new devices, adjuvant therapies, drug development, operative complications, functional outcome, and quality of life characterize the presentations and discussions at the meetings of the Musculoskeletal Tumor Society (MSTS) and the International Society of Limb Salvage (ISOLS). The manuscripts in this symposium make useful contributions to our understanding of the causes, behaviors, and consequences of musculoskeletal tumors.