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Clinical Orthopaedics and Related Research®
Published in: Clinical Orthopaedics and Related Research® 2/2015

01-02-2015 | CORR Insights

CORR Insights®: Do Serologic and Synovial Tests Help Diagnose Infection in Revision Hip Arthroplasty With Metal-on-metal Bearings or Corrosion?

Author: Carl Deirmengian, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 2/2015

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Excerpt

The generation of metal debris and corrosion products by hip arthroplasties can lead to an adverse local tissue reaction (ALTR), which often presents similarly to periprosthetic joint infection (PJI). Although an ALTR to metal is most commonly thought of to occur in the context of a metal-on-metal (MoM) arthroplasty, there is increasing awareness that metal debris and corrosion products can also be generated at the head-neck junction of any bearing combination [1]. …
Literature
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Cooper HJ, Della Valle CJ, Berger RA, Tetreault M, Paprosky WG, Sporer SM, Jacobs JJ. Corrosion at the head-neck taper as a cause for adverse local tissue reactions after total hip arthroplasty. J Bone Joint Surg Am. 2012;94:1655–1661.PubMed
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Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Combined Measurement of Synovial Fluid alpha-Defensin and C-Reactive Protein Levels: Highly Accurate for Diagnosing Periprosthetic Joint Infection. J Bone Joint Surg Am. 2014;96:1439–1445.PubMedCrossRef
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Jacovides CL, Parvizi J, Adeli B, Jung KA. Molecular markers for diagnosis of periprosthetic joint infection. Arthroplasty. 2011;26:99–103 e101.
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Shanmugasundaram S, Ricciardi BF, Briggs TW, Sussmann PS, Bostrom MP. Evaluation and management of periprosthetic joint infection-an international, multicenter study. HSS J. 2014;10:36–44.PubMedCrossRef
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Wang JY, Tsukayama DT, Wicklund BH, Gustilo RB. Inhibition of T and B cell proliferation by titanium, cobalt, and chromium: role of IL-2 and IL-6. J Biomed Mater Res. 1996;32:655–661.PubMedCrossRef
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Wang JY, Wicklund BH, Gustilo RB, Tsukayama DT. Prosthetic metals impair murine immune response and cytokine release in vivo and in vitro. J Orthop Res. 1997;15:688–699.PubMedCrossRef
Metadata
Title
CORR Insights®: Do Serologic and Synovial Tests Help Diagnose Infection in Revision Hip Arthroplasty With Metal-on-metal Bearings or Corrosion?
Author
Carl Deirmengian, MD
Publication date
01-02-2015
Publisher
Springer US
Published in
Clinical Orthopaedics and Related Research® / Issue 2/2015
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-014-3972-4

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