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Clinical Orthopaedics and Related Research®

Published in:

01-12-2014 | Symposium: ABJS Carl T. Brighton Workshop on Implant Wear and Tribocorrosion of Total Joint Replacements

Do Genetic Susceptibility, Toll-like Receptors, and Pathogen-associated Molecular Patterns Modulate the Effects of Wear?

Author: Edward M. Greenfield, PhD

Published in: Clinical Orthopaedics and Related Research® | Issue 12/2014

Abstract

Background

Overwhelming evidence supports the concept that wear particles are the primary initiator of aseptic loosening of orthopaedic implants. It is likely, however, that other factors modulate the biologic response to wear particles. This review focuses on three potential other factors: genetic susceptibility, Toll-like receptors (TLRs), and bacterial pathogen-associated molecular patterns (PAMPs).

Where Are We Now?

Considerable evidence is emerging that both genetic susceptibility and TLR activation are important factors that modulate the biologic response to wear particles, but it remains controversial whether bacterial PAMPs also do so.

Where Do We Need to Go?

Detailed understanding of the roles of these other factors may lead to identification of novel therapeutic targets for patients with aseptic loosening.

How Do We Get There?

Highest priority should be given to polymorphism replication studies with large numbers of patients and studies to replicate the reported correlation between bacterial biofilms and the severity of aseptic loosening.

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Title: Do Genetic Susceptibility, Toll-like Receptors, and Pathogen-associated Molecular Patterns Modulate the Effects of Wear?
Author: Edward M. Greenfield, PhD
Publication date: 01-12-2014
Publisher: Springer US
Published in: Clinical Orthopaedics and Related Research® / Issue 12/2014
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-014-3786-4

At a glance: The STEP trials

Springer Medicine

Do Genetic Susceptibility, Toll-like Receptors, and Pathogen-associated Molecular Patterns Modulate the Effects of Wear?

Abstract

Background

Where Are We Now?

Where Do We Need to Go?

How Do We Get There?

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Where Are We Now?

Where Do We Need to Go?

How Do We Get There?

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Other articles of this Issue 12/2014

Ilizarov Fixator Combined With an Intramedullary Nail for Tibial Nonunions With Bone Loss: Is It Effective?

CORR Insights®: Comorbidities in Patients Undergoing Total Knee Arthroplasty: Do They Influence Hospital Costs and Length of Stay?

Letter to the Editor: Effectiveness of Sustained Stretching of the Inferior Capsule in the Management of a Frozen Shoulder

Giants In Orthopaedic Surgery: Robert Bruce Salter CC, MD, FRCSC

CORR Insights®: Apical and Intermediate Anchors Without Fusion Improve Cobb Angle and Thoracic Kyphosis in Early-onset Scoliosis

Editorial: Thanks to Our Peer Reviewers