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Published in: Clinical Orthopaedics and Related Research® 7/2012

01-07-2012 | Symposium: Retrieval Studies

Constrained Cups Appear Incapable of Meeting the Demands of Revision THA

Authors: Philip C. Noble, PhD, Salim K. Durrani, MD, Molly M. Usrey, BS, Kenneth B. Mathis, MD, Nikolaos V. Bardakos, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 7/2012

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Abstract

Background

Failure rates of constrained cups for treating recurrent dislocation in revision THA range from 40% to 100%. Although constrained liners are intended to stabilize the hip by mechanically preventing dislocation, the resulting loss of range of motion may lead to impingement and, ultimately, implant failure.

Questions/purposes

We therefore documented the mechanisms of failure of constrained acetabular cups in revision THA and determined the type and severity of damage (wear, fracture, and impingement) that occurs in situ.

Methods

We retrieved 57 constrained components of four different designs at revision THA and examined for the presence of rim impingement, oxidation, cracks within the liner, backside wear, pitting, scratching, abrasion, burnishing, and the presence of embedded particles. Articular wear was calculated from the volume of the concave articular bearing surface, which was measured using the fluid displacement method.

Results

Failure of the locking ring was responsible for 51% of failures, whereas 28% of revisions were the result of acetabular cup loosening, 6% backside wear, and 22% infection. Impingement damage of the rim of the polyethylene liner was seen in all retrievals with moderate or severe damage in 54%. The average volumetric wear rate of the articular surface was 95 mm3/year.

Conclusions

Failure of the locking liner ring and loosening of the acetabular cup are the primary causes of mechanical failure with constrained liners; polyethylene is an inadequate material for restricting motion of the hip to prevent instability. The durability of these devices is unlikely to improve unless the mechanical demands are modified through increased range of motion leading to less frequent rim impingement.
Appendix
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Literature
1.
go back to reference Anderson MJ, Murray WR, Skinner HB. Constrained acetabular components. J Arthroplasty. 1994;9:17–23.PubMedCrossRef Anderson MJ, Murray WR, Skinner HB. Constrained acetabular components. J Arthroplasty. 1994;9:17–23.PubMedCrossRef
2.
go back to reference Berend KR, Lombardi AV Jr, Mallory TH, Adams JB, Russell JH, Groseth KL. The long-term outcome of 755 consecutive constrained acetabular components in total hip arthroplasty: examining the successes and failures. J Arthroplasty. 2005;20:93–102.PubMedCrossRef Berend KR, Lombardi AV Jr, Mallory TH, Adams JB, Russell JH, Groseth KL. The long-term outcome of 755 consecutive constrained acetabular components in total hip arthroplasty: examining the successes and failures. J Arthroplasty. 2005;20:93–102.PubMedCrossRef
3.
go back to reference Berend KR, Lombardi AV Jr, Welch M, Adams JB. A constrained device with increased range of motion prevents early dislocation. Clin Orthop Relat Res. 2006;447:70–75.PubMedCrossRef Berend KR, Lombardi AV Jr, Welch M, Adams JB. A constrained device with increased range of motion prevents early dislocation. Clin Orthop Relat Res. 2006;447:70–75.PubMedCrossRef
4.
go back to reference Birman MV, Noble PC, Conditt MA, Li S, Mathis KB. Cracking and impingement in ultra-high-molecular-weight polyethylene acetabular liners. J Arthroplasty. 2005;20:87–92.PubMedCrossRef Birman MV, Noble PC, Conditt MA, Li S, Mathis KB. Cracking and impingement in ultra-high-molecular-weight polyethylene acetabular liners. J Arthroplasty. 2005;20:87–92.PubMedCrossRef
5.
go back to reference Bitsch RG, Loidolt T, Heisel C, Ball S, Schmalzried TP. Reduction of osteolysis with use of Marathon cross-linked polyethylene. A concise follow-up, at a minimum of five years, of a previous report. J Bone Joint Surg Am. 2008;90:1487–1491.PubMedCrossRef Bitsch RG, Loidolt T, Heisel C, Ball S, Schmalzried TP. Reduction of osteolysis with use of Marathon cross-linked polyethylene. A concise follow-up, at a minimum of five years, of a previous report. J Bone Joint Surg Am. 2008;90:1487–1491.PubMedCrossRef
6.
go back to reference Boucher HR, Lynch C, Young AM, Engh CA Jr, Engh C Sr. Dislocation after polyethylene liner exchange in total hip arthroplasty. J Arthroplasty. 2003;18:654.PubMedCrossRef Boucher HR, Lynch C, Young AM, Engh CA Jr, Engh C Sr. Dislocation after polyethylene liner exchange in total hip arthroplasty. J Arthroplasty. 2003;18:654.PubMedCrossRef
7.
go back to reference Bradford L, Baker DA, Graham J, Chawan A, Ries MD, Pruitt LA. Wear and surface cracking in early retrieved highly cross-linked polyethylene acetabular liners. J Bone Joint Surg Am. 2004;86:1271–1282.PubMed Bradford L, Baker DA, Graham J, Chawan A, Ries MD, Pruitt LA. Wear and surface cracking in early retrieved highly cross-linked polyethylene acetabular liners. J Bone Joint Surg Am. 2004;86:1271–1282.PubMed
8.
go back to reference Bryan WJ, Reeve RE. Dislocation and failure of an articulated total hip replacement. A case report. Orthopedics. 1986;9:1113–1115.PubMed Bryan WJ, Reeve RE. Dislocation and failure of an articulated total hip replacement. A case report. Orthopedics. 1986;9:1113–1115.PubMed
9.
go back to reference Burroughs BR, Golladay GJ, Hallstrom B, Harris WH. A novel constrained acetabular liner design with increased range of motion. J Arthroplasty. 2001;16:31–36. PubMedCrossRef Burroughs BR, Golladay GJ, Hallstrom B, Harris WH. A novel constrained acetabular liner design with increased range of motion. J Arthroplasty. 2001;16:31–36. PubMedCrossRef
10.
go back to reference Calvert GT, Devane PA, Fielden J, Adams K, Horne JG. A double-blind, prospective, randomized controlled trial comparing highly cross-linked and conventional polyethylene in primary total hip arthroplasty. J Arthroplasty. 2009;24:505–510.PubMedCrossRef Calvert GT, Devane PA, Fielden J, Adams K, Horne JG. A double-blind, prospective, randomized controlled trial comparing highly cross-linked and conventional polyethylene in primary total hip arthroplasty. J Arthroplasty. 2009;24:505–510.PubMedCrossRef
11.
go back to reference Cates HE, Faris PM, Keating EM, Ritter MA. Polyethylene wear in cemented metal-backed acetabular cups. J Bone Joint Surg Br. 1993;75:249–253.PubMed Cates HE, Faris PM, Keating EM, Ritter MA. Polyethylene wear in cemented metal-backed acetabular cups. J Bone Joint Surg Br. 1993;75:249–253.PubMed
12.
go back to reference Charnley J. The long-term results of low-friction arthroplasty of the hip performed as a primary intervention. J Bone Joint Surg Br. 1972;54:61–76.PubMed Charnley J. The long-term results of low-friction arthroplasty of the hip performed as a primary intervention. J Bone Joint Surg Br. 1972;54:61–76.PubMed
13.
go back to reference Chuter GSJ, Cloke DJ, Mahommed A, Partington PF, Green SM. Wear analysis of failed acetabular polyethylene. A comparison of analytical methods. J Bone Joint Surg Br. 2007;89:273–279.PubMedCrossRef Chuter GSJ, Cloke DJ, Mahommed A, Partington PF, Green SM. Wear analysis of failed acetabular polyethylene. A comparison of analytical methods. J Bone Joint Surg Br. 2007;89:273–279.PubMedCrossRef
14.
go back to reference Cooke CC, Hozack W, Lavernia C, Sharkey P, Shastri S, Rothman RH. Early failure mechanisms of constrained tripolar acetabular sockets used in revision total hip arthroplasty. J Arthroplasty. 2003;18:827–833.PubMedCrossRef Cooke CC, Hozack W, Lavernia C, Sharkey P, Shastri S, Rothman RH. Early failure mechanisms of constrained tripolar acetabular sockets used in revision total hip arthroplasty. J Arthroplasty. 2003;18:827–833.PubMedCrossRef
15.
go back to reference Della Valle AG, Rana A, Furman B, Sculco TP, Salvati EA. Backside wear is low in retrieved modern, modular, and nonmodular acetabular liners. Clin Orthop Relat Res. 2005;440:184–191.PubMedCrossRef Della Valle AG, Rana A, Furman B, Sculco TP, Salvati EA. Backside wear is low in retrieved modern, modular, and nonmodular acetabular liners. Clin Orthop Relat Res. 2005;440:184–191.PubMedCrossRef
16.
go back to reference Della Valle CJ, Chang D, Sporer S, Berger RA, Rosenberg AG, Paprosky WG. High failure rate of a constrained acetabular liner in revision total hip arthroplasty. J Arthroplasty. 2005;20(Suppl 3):103–107.PubMedCrossRef Della Valle CJ, Chang D, Sporer S, Berger RA, Rosenberg AG, Paprosky WG. High failure rate of a constrained acetabular liner in revision total hip arthroplasty. J Arthroplasty. 2005;20(Suppl 3):103–107.PubMedCrossRef
17.
go back to reference Earll MD, Fehring TK, Griffin WL. Success rate of modular component exchange for the treatment of unstable total hip arthroplasty. J Arthroplasty. 2002;17:864.PubMedCrossRef Earll MD, Fehring TK, Griffin WL. Success rate of modular component exchange for the treatment of unstable total hip arthroplasty. J Arthroplasty. 2002;17:864.PubMedCrossRef
18.
go back to reference Fricka KB, Marshall A, Paprosky WG. Constrained liners in revision total hip arthroplasty: an overuse syndrome. J Arthroplasty. 2006;21:121–125.PubMedCrossRef Fricka KB, Marshall A, Paprosky WG. Constrained liners in revision total hip arthroplasty: an overuse syndrome. J Arthroplasty. 2006;21:121–125.PubMedCrossRef
19.
go back to reference Goetz DD, Capello WN, Callaghan JJ, Brown TD, Johnston RC. Salvage of a recurrently dislocating total hip prosthesis with use of a constrained acetabular component. A retrospective analysis of fifty-six cases. J Bone Joint Surg Am. 1998;80:502–509.PubMed Goetz DD, Capello WN, Callaghan JJ, Brown TD, Johnston RC. Salvage of a recurrently dislocating total hip prosthesis with use of a constrained acetabular component. A retrospective analysis of fifty-six cases. J Bone Joint Surg Am. 1998;80:502–509.PubMed
20.
go back to reference Guyen O, Lewallen DG, Cabanela ME. Modes of failure of Osteonics constrained tripolar implants: a retrospective analysis of forty-three failed implants. J Bone Joint Surg Am. 2008;90:1553–1560.PubMedCrossRef Guyen O, Lewallen DG, Cabanela ME. Modes of failure of Osteonics constrained tripolar implants: a retrospective analysis of forty-three failed implants. J Bone Joint Surg Am. 2008;90:1553–1560.PubMedCrossRef
21.
go back to reference Hall RM, Siney P, Unsworth A, Wroblewski BM. Prevalence of impingement in explanted Charnley acetabular components. J Orthop Sci. 1998;3:204–208.PubMedCrossRef Hall RM, Siney P, Unsworth A, Wroblewski BM. Prevalence of impingement in explanted Charnley acetabular components. J Orthop Sci. 1998;3:204–208.PubMedCrossRef
22.
go back to reference Hammerberg EM, Wan Z, Dastane M, Dorr LD. Wear and range of motion of different femoral head sizes. J Arthroplasty. 2010;25:839–843.PubMedCrossRef Hammerberg EM, Wan Z, Dastane M, Dorr LD. Wear and range of motion of different femoral head sizes. J Arthroplasty. 2010;25:839–843.PubMedCrossRef
23.
go back to reference Heiner AD, Lundberg HJ, Baer TE, Pedersen DR, Callaghan JJ, Brown TD. Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface. J Biomech. 2008;41:2090–2096.PubMedCrossRef Heiner AD, Lundberg HJ, Baer TE, Pedersen DR, Callaghan JJ, Brown TD. Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface. J Biomech. 2008;41:2090–2096.PubMedCrossRef
24.
go back to reference Hirakawa K, Jacobs JJ, Urban R, Saito T. Mechanisms of failure of total hip replacements: lessons learned from retrieval studies. Clin Orthop Relat Res. 2004;420:10–. Hirakawa K, Jacobs JJ, Urban R, Saito T. Mechanisms of failure of total hip replacements: lessons learned from retrieval studies. Clin Orthop Relat Res. 2004;420:10–.
25.
go back to reference Jasty M, Goetz DD, Bragdon CR, Lee KR, Hanson AE, Elder JR, Harris WH. Wear of polyethylene acetabular components in total hip arthroplasty. An analysis of one hundred and twenty-eight components retrieved at autopsy or revision operations. J Bone Joint Surg Am. 1997;79:349–358.PubMedCrossRef Jasty M, Goetz DD, Bragdon CR, Lee KR, Hanson AE, Elder JR, Harris WH. Wear of polyethylene acetabular components in total hip arthroplasty. An analysis of one hundred and twenty-eight components retrieved at autopsy or revision operations. J Bone Joint Surg Am. 1997;79:349–358.PubMedCrossRef
26.
go back to reference Joshi A, Ilchmann T, Markovic L. Socket wear in bilateral simultaneous total hip arthroplasty. J Arthroplasty. 2001;16:117–120.PubMedCrossRef Joshi A, Ilchmann T, Markovic L. Socket wear in bilateral simultaneous total hip arthroplasty. J Arthroplasty. 2001;16:117–120.PubMedCrossRef
27.
go back to reference Kabo JM, Gebhard JS, Loren G, Amstutz HC. In vivo wear of polyethylene acetabular components. J Bone Joint Surg Br. 1993;75:254–258.PubMed Kabo JM, Gebhard JS, Loren G, Amstutz HC. In vivo wear of polyethylene acetabular components. J Bone Joint Surg Br. 1993;75:254–258.PubMed
28.
go back to reference Kaper BP, Bernini PM. Failure of a constrained acetabular prosthesis of a total hip arthroplasty. A report of four cases. J Bone Joint Surg Am. 1998;80:561–565.PubMed Kaper BP, Bernini PM. Failure of a constrained acetabular prosthesis of a total hip arthroplasty. A report of four cases. J Bone Joint Surg Am. 1998;80:561–565.PubMed
29.
go back to reference Khan RJ, Fick D, Alakeson R, Li MG, Nivbrant B, Wood D. The constrained acetabular component for hip instability. J Arthroplasty. 2007;22:377–382.PubMedCrossRef Khan RJ, Fick D, Alakeson R, Li MG, Nivbrant B, Wood D. The constrained acetabular component for hip instability. J Arthroplasty. 2007;22:377–382.PubMedCrossRef
30.
go back to reference Kotwal RS, Ganapathi M, John A, Maheson M, Jones SA. Outcome of treatment for dislocation after primary total hip replacement. J Bone Joint Surg Br. 2009;91:321–326.PubMedCrossRef Kotwal RS, Ganapathi M, John A, Maheson M, Jones SA. Outcome of treatment for dislocation after primary total hip replacement. J Bone Joint Surg Br. 2009;91:321–326.PubMedCrossRef
31.
go back to reference Lachiewicz PF, Kelley SS. The use of constrained components in total hip arthroplasty. J Am Acad Orthop Surg. 2002;10:233–238.PubMed Lachiewicz PF, Kelley SS. The use of constrained components in total hip arthroplasty. J Am Acad Orthop Surg. 2002;10:233–238.PubMed
32.
go back to reference Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174.PubMedCrossRef Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–174.PubMedCrossRef
33.
go back to reference Lavigne MJ, Sanchez AA, Coutts RD. Recurrent dislocation after total hip arthroplasty: treatment with an Achilles tendon allograft. J Arthroplasty 2001;16(Suppl 1):13–18.PubMedCrossRef Lavigne MJ, Sanchez AA, Coutts RD. Recurrent dislocation after total hip arthroplasty: treatment with an Achilles tendon allograft. J Arthroplasty 2001;16(Suppl 1):13–18.PubMedCrossRef
34.
go back to reference Li E, Medling JB, Ritter MA, Keating EM, Faris PM. The natural history of a posteriorly dislocated total hip replacement. J Arthroplasty. 1999;14:964.PubMedCrossRef Li E, Medling JB, Ritter MA, Keating EM, Faris PM. The natural history of a posteriorly dislocated total hip replacement. J Arthroplasty. 1999;14:964.PubMedCrossRef
35.
go back to reference Lombardi AV Jr, Mallory TH, Kraus TJ, Vaughn BK. Preliminary report on the S-ROM constraining acetabular insert: a retrospective clinical experience. Orthopedics. 1991;14:297–303.PubMed Lombardi AV Jr, Mallory TH, Kraus TJ, Vaughn BK. Preliminary report on the S-ROM constraining acetabular insert: a retrospective clinical experience. Orthopedics. 1991;14:297–303.PubMed
36.
go back to reference Lundberg HJ, Pedersen DR, Baer TE, Muste M, Callaghan JJ, Brown TD. Effects of implant design parameters on fluid convection, potentiating third-body debris ingress into the bearing surface during THA impingement/subluxation. J Biomech. 2007;40:1676–1685.PubMedCrossRef Lundberg HJ, Pedersen DR, Baer TE, Muste M, Callaghan JJ, Brown TD. Effects of implant design parameters on fluid convection, potentiating third-body debris ingress into the bearing surface during THA impingement/subluxation. J Biomech. 2007;40:1676–1685.PubMedCrossRef
37.
go back to reference Masaoka T, Clarke IC, Yamamoto K, Tamura J, Williams PA, Good VD, Shoji H, Imakiire A. Validation of volumetric and linear wear measurements in UHMWPE cups-a hip simulator analysis. Wear. 2003;254;391–8.CrossRef Masaoka T, Clarke IC, Yamamoto K, Tamura J, Williams PA, Good VD, Shoji H, Imakiire A. Validation of volumetric and linear wear measurements in UHMWPE cups-a hip simulator analysis. Wear. 2003;254;391–8.CrossRef
38.
go back to reference Morrey BF. Difficult complications after hip joint replacement. Dislocation. Clin Orthop Relat Res. 1997;344:179–187.PubMedCrossRef Morrey BF. Difficult complications after hip joint replacement. Dislocation. Clin Orthop Relat Res. 1997;344:179–187.PubMedCrossRef
39.
go back to reference Parvizi J, Picinic E, Sharkey PF. Revision total hip arthroplasty for instability: surgical techniques and principles. J Bone Joint Surg Am. 2008;90:1134–1142.PubMed Parvizi J, Picinic E, Sharkey PF. Revision total hip arthroplasty for instability: surgical techniques and principles. J Bone Joint Surg Am. 2008;90:1134–1142.PubMed
40.
go back to reference Pattyn C, De Haan R, Kloek A, Van Marle G, De Smet K. Complications encountered with the use of constrained acetabular prostheses in total hip arthroplasty. J Arthroplasty. 2010;254:287–294.CrossRef Pattyn C, De Haan R, Kloek A, Van Marle G, De Smet K. Complications encountered with the use of constrained acetabular prostheses in total hip arthroplasty. J Arthroplasty. 2010;254:287–294.CrossRef
41.
go back to reference Schmalzried TP, Callaghan JJ. Wear in total hip and knee replacements. J Bone Joint Surg Am. 1999;81:115–136.PubMed Schmalzried TP, Callaghan JJ. Wear in total hip and knee replacements. J Bone Joint Surg Am. 1999;81:115–136.PubMed
42.
go back to reference Sethuraman V, Hozack WJ, Sharkey PF. Pseudoaneurysm of femoral artery after revision total hip arthroplasty with a constrained cup. J Arthroplasty. 2000;15:531.PubMedCrossRef Sethuraman V, Hozack WJ, Sharkey PF. Pseudoaneurysm of femoral artery after revision total hip arthroplasty with a constrained cup. J Arthroplasty. 2000;15:531.PubMedCrossRef
43.
go back to reference Shah SN, Kaye RJ, Kelly NH, Su EP, Padgett DE, Wright TM. Retrieval analysis of failed constrained acetabular liners. J Arthroplasty. 2009;24(Suppl):54–57.PubMedCrossRef Shah SN, Kaye RJ, Kelly NH, Su EP, Padgett DE, Wright TM. Retrieval analysis of failed constrained acetabular liners. J Arthroplasty. 2009;24(Suppl):54–57.PubMedCrossRef
44.
go back to reference Shon WY, Baldini T, Peterson MG, Wright TM, Salvati EA. Impingement in total hip arthroplasty a study of retrieved acetabular components. J Arthroplasty. 2005;20:427–435.PubMedCrossRef Shon WY, Baldini T, Peterson MG, Wright TM, Salvati EA. Impingement in total hip arthroplasty a study of retrieved acetabular components. J Arthroplasty. 2005;20:427–435.PubMedCrossRef
45.
go back to reference Shrader MW, Parvisi J, Lewallen DG. The use of a constrained acetabular component to treat instability after total hip arthroplasty. J Bone Joint Surg Am. 2003;85:2179.PubMed Shrader MW, Parvisi J, Lewallen DG. The use of a constrained acetabular component to treat instability after total hip arthroplasty. J Bone Joint Surg Am. 2003;85:2179.PubMed
46.
go back to reference Stanton DA, Bruce WJ, Goldberg JA, Walsh W. Salvaging unstable or recurrent dislocating total hip arthroplasty with the constrained acetabular component. J Orthop Surg (Hong Kong). 2002;10:165–169. Stanton DA, Bruce WJ, Goldberg JA, Walsh W. Salvaging unstable or recurrent dislocating total hip arthroplasty with the constrained acetabular component. J Orthop Surg (Hong Kong). 2002;10:165–169.
47.
go back to reference Sychterz CJ, Engh CA Jr, Shah N, Engh CA Sr. Radiographic evaluation of penetration by the femoral head into the polyethylene liner over time. J Bone Joint Surg Am. 1997;79:1040–1046.PubMed Sychterz CJ, Engh CA Jr, Shah N, Engh CA Sr. Radiographic evaluation of penetration by the femoral head into the polyethylene liner over time. J Bone Joint Surg Am. 1997;79:1040–1046.PubMed
48.
go back to reference Usrey MM, Noble PC, Rudner LJ, Conditt MA, Birman MV, Santore RF, Mathis KB. Does neck/liner impingement increase wear of ultrahigh-molecular-weight polyethylene liners? J Arthroplasty. 2006;21:65–71.PubMedCrossRef Usrey MM, Noble PC, Rudner LJ, Conditt MA, Birman MV, Santore RF, Mathis KB. Does neck/liner impingement increase wear of ultrahigh-molecular-weight polyethylene liners? J Arthroplasty. 2006;21:65–71.PubMedCrossRef
49.
go back to reference Williams JT Jr, Ragland PS, Clarke S. Constrained components for the unstable hip following total hip arthroplasty: a literature review. Int Orthop. 2007;31:273–277.PubMedCrossRef Williams JT Jr, Ragland PS, Clarke S. Constrained components for the unstable hip following total hip arthroplasty: a literature review. Int Orthop. 2007;31:273–277.PubMedCrossRef
50.
go back to reference Yang C, Goodman SB. Outcome and complications of constrained acetabular components. Orthopedics. 2009;32:115.PubMed Yang C, Goodman SB. Outcome and complications of constrained acetabular components. Orthopedics. 2009;32:115.PubMed
51.
go back to reference Yun AG, Padgett D, Pellicci P, Dorr LD. Constrained acetabular liners: mechanisms of failure. J Arthroplasty. 2005;20:536–541.PubMedCrossRef Yun AG, Padgett D, Pellicci P, Dorr LD. Constrained acetabular liners: mechanisms of failure. J Arthroplasty. 2005;20:536–541.PubMedCrossRef
Metadata
Title
Constrained Cups Appear Incapable of Meeting the Demands of Revision THA
Authors
Philip C. Noble, PhD
Salim K. Durrani, MD
Molly M. Usrey, BS
Kenneth B. Mathis, MD
Nikolaos V. Bardakos, MD
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 7/2012
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-011-2212-4

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