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Clinical Orthopaedics and Related Research®
Published in: Clinical Orthopaedics and Related Research® 10/2011

01-10-2011 | Symposium: Clinically Relevant Strategies for Treating Cartilage and Meniscal Pathology

Frictional Properties of the Meniscus Improve After Scaffold-augmented Repair of Partial Meniscectomy: A Pilot Study

Authors: Natalie K. Galley, MS, Jason P. Gleghorn, PhD, Scott Rodeo, MD, Russell F. Warren, MD, Suzanne A. Maher, PhD, Lawrence J. Bonassar, PhD

Published in: Clinical Orthopaedics and Related Research® | Issue 10/2011

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Abstract

Background

To prevent further degeneration, it is desirable to fill a meniscal defect with a supportive scaffold that mimics the mechanics of native tissue. Degradable porous scaffolds have been used, but it is unclear whether the tissue that fills the site of implantation is mechanically adequate, particularly with respect to frictional performance.

Questions/purposes

We therefore determined the frictional behavior of native and engineered meniscal replacement tissue from in vivo implantation over time.

Methods

We evaluated boundary and mixed-mode friction coefficients of tissue generated in porous polyurethane scaffolds used to augment the repair of the meniscus of 13 skeletally mature sheep after partial meniscectomy. Implants were removed for evaluation at 3, 6, and 12 months. The friction coefficient, aggregate modulus, and hydraulic permeability were evaluated for tissue harvested from native meniscus adjacent to the implants, native meniscus from the intact contralateral knee, and repair tissue from the site of the scaffold implantation. The equilibrium friction coefficient (μeq) was measured in the presence of a lubricant bath of either phosphate-buffered saline (PBS) or equine synovial fluid (ESF).

Results

Boundary μeq in PBS of engineered meniscus improved with time and was similar to native tissue after 6 months. ESF enhanced lubrication for all samples at nearly all time points demonstrating the efficacy of ESF as a joint lubricant for repair tissue as well as native meniscus. Modulus increased and permeability decreased with implantation, likely as a result of tissue ingrowth.

Conclusions

Promoting tissue ingrowth into porous scaffolds is a potential strategy for improving friction performance in meniscal repair.
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Metadata
Title
Frictional Properties of the Meniscus Improve After Scaffold-augmented Repair of Partial Meniscectomy: A Pilot Study
Authors
Natalie K. Galley, MS
Jason P. Gleghorn, PhD
Scott Rodeo, MD
Russell F. Warren, MD
Suzanne A. Maher, PhD
Lawrence J. Bonassar, PhD
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 10/2011
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-011-1854-6

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