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Clinical Orthopaedics and Related Research®

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01-09-2008 | Symposium: Molecular Genetics in Sarcoma

Editorial Comment: Cancer Biology – Lessons Learned From Sarcoma

Authors: John H. Healey, MD, FACS, Bang H. Hoang, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 9/2008

Excerpt

Sarcoma biology has been the foundation of our understanding the molecular, immunologic, and viral bases of cancer. In the premodern era of orthopaedics, before arthroplasty and arthroscopy, bone and soft tissue sarcoma research established basic concepts of cancer biology. Virtually every major advance in our understanding of how genetic code aberrations cause cancer originated in investigations of sarcoma. Retinoblastoma gene and osteogenic sarcoma [1, 4], Rous sarcoma virus (src gene) [7], Harvey and Kirsten sarcoma viruses (H-ras and V-ras) [8], and Li-Fraumeni syndrome (p53) [6], are important examples. Despite these contributions, during the last quarter-century most serious investigators focused on liquid (hematopoietic) cancers and eschewed the more difficult solid tumors. …

Benedict WF, Fung YK, Murphree AL. The gene responsible for the development of retinoblastoma, osteosarcoma. Cancer. 1988;62(Suppl 8):1691–1694.PubMedCrossRef

Demetri GD. Identification, treatment of chemoresistant inoperable or metastatic GIST: experience with the selective tyrosine kinase inhibitor imatinib mesylate (STI571). Eur J Cancer. 2002;38(Suppl 5):S52–S59.PubMedCrossRef

Dylan B. The times they are a-changin’. The Times They Are A-Changin’. Columbia Records; 1964.

Friend SH, Horowitz JM, Gerber MR, Wang XF, Bogenmann E, Li FP, Weinberg RA. Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci USA. 1987;84:9059–9063.

Koshland DE Jr. Molecule of the year. Science. 1993;262:1953.PubMedCrossRef

Masuda H, Miller C, Koeffler HP, Battifora H, Cline MJ. Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci USA. 1987;84:7716–7719.

Parker RC, Varmus HE, Bishop JM. Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions. Proc Natl Acad Sci USA. 1981;78:5842–5846.

Rasheed S, Young HA. Induction of fibrosarcoma by rat sarcoma virus. Virology. 1982;15(118):219–224.CrossRef

Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group. Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones. J Bone Joint Surg Am. 2007;89:2113–2123.CrossRef

Title: Editorial Comment: Cancer Biology – Lessons Learned From Sarcoma
Authors: John H. Healey, MD, FACS
Bang H. Hoang, MD
Publication date: 01-09-2008
Publisher: Springer-Verlag
Published in: Clinical Orthopaedics and Related Research® / Issue 9/2008
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-008-0353-x

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Editorial Comment: Cancer Biology – Lessons Learned From Sarcoma

Excerpt

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