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Clinical Orthopaedics and Related Research®
Published in: Clinical Orthopaedics and Related Research® 8/2008

01-08-2008 | Symposium: New Approaches to Allograft Transplantation

Fresh Osteochondral Allografts for Posttraumatic Knee Defects: Long-term Followup

Authors: A. E. Gross, MD, FRCSC, O.Ont, W. Kim, MD, F. Las Heras, MD, D. Backstein, D, MD, MEd, FRCSC, O. Safir, MD, FRCSC, K. P. H. Pritzker, MD, FRCPC

Published in: Clinical Orthopaedics and Related Research® | Issue 8/2008

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Abstract

Fresh osteochondral allograft transplantation has been an effective treatment option with promising long-term clinical outcomes for focal posttraumatic defects in the knee for young, active individuals. We examined histologic features of 35 fresh osteochondral allograft specimens retrieved at the time of subsequent graft revision, osteotomy, or TKA. Graft survival time ranged from 1 to 25 years based on their time to reoperation. Histologic features of early graft failures were lack of chondrocyte viability and loss of matrix cationic staining. Histologic features of late graft failures were fracture through the graft, active and incomplete remodeling of the graft bone by the host bone, and resorption of the graft tissue by synovial inflammatory activity at graft edges. Histologic features associated with long-term allograft survival included viable chondrocytes, functional preservation of matrix, and complete replacement of the graft bone with the host bone. Given chondrocyte viability, long-term allograft survival depends on graft stability by rigid fixation of host bone to graft bone. With the stable osseous graft base, the hyaline cartilage portion of the allograft can survive and function for 25 years or more.
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Metadata
Title
Fresh Osteochondral Allografts for Posttraumatic Knee Defects: Long-term Followup
Authors
A. E. Gross, MD, FRCSC, O.Ont
W. Kim, MD
F. Las Heras, MD
D. Backstein, D, MD, MEd, FRCSC
O. Safir, MD, FRCSC
K. P. H. Pritzker, MD, FRCPC
Publication date
01-08-2008
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 8/2008
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-008-0282-8

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