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01-10-2015 | Neuromuscular Disorders (SA Rudnicki, Section Editor)

Vasculitic Neuropathies

Authors: Elie Naddaf, MD, P. James Bonham Dyck, MD

Published in: Current Treatment Options in Neurology | Issue 10/2015

Opinion statement

From pathological standpoint, we divide vasculitic neuropathies in two categories: nerve large arteriole vasculitides and nerve microvasculitis. It is also important to determine whether a large arteriole vasculitis has an infectious etiology as it entails different treatment approach. Treatment of non-infectious large arteriole vasculitides consists initially of induction therapy with corticosteroids. Adding an immunosuppressant, mainly cyclophosphamide, is often needed. Treatment of infectious large arteriole vasculitides needs a multidisciplinary approach to target both the underlying infection and the vasculitis. Corticosteroids are the first-line therapy for classic non-systemic vasculitic neuropathy. Stable or improving patients without biopsy evidence of active vasculitis can be either observed or treated. Currently, adding an immunosuppressant is only indicated for patients who continue to progress on corticosteroids alone or patients with a rapidly progressive course. The treatment of the radiculoplexus neuropathies such as diabetic lumbosacral radiculoplexus neuropathy, lumbosacral radiculoplexus neuropathy (in non-diabetic patients), and diabetic cervical radiculoplexus neuropathy, as well as painless diabetic motor neuropathy, is not well established yet. We treat patients, if they present early on in the disease course or if they have severe disabling symptoms, with IV methylprednisolone 1 g once a week for 12 weeks.

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Title: Vasculitic Neuropathies
Authors: Elie Naddaf, MD
P. James Bonham Dyck, MD
Publication date: 01-10-2015
Publisher: Springer US
Published in: Current Treatment Options in Neurology / Issue 10/2015
Print ISSN: 1092-8480
Electronic ISSN: 1534-3138
DOI: https://doi.org/10.1007/s11940-015-0374-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Vasculitic Neuropathies

Opinion statement

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Opinion statement

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